alexa Development of Leptospira Killed Whole Culture Vaccine
ISSN: 2157-7560

Journal of Vaccines & Vaccination
Open Access

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Research Article

Development of Leptospira Killed Whole Culture Vaccine Using Different Adjuvants and Evaluation of Humoral Immune Response in Hamsters

Reza Banihashemi*

Razi Vaccine Serum Research Institute, Iran

*Corresponding Author:
Reza Banihashemi
Ph.D Student of Medical Immunology
Alborz, Kraj, Hesarak, Beheshti Blv
Razi Vaccine Serum Research Institute
Postal code: 3197619751, Iran
Tel: +98-26-345-027-49; 989-126-134-324
E-mail: [email protected]

Received date: March 10, 2013; Accepted date: April 26, 2013; Published date: May 28, 2013

Citation: Banihashemi R (2013) Development of Leptospira Killed Whole Culture Vaccine Using Different Adjuvants and Evaluation of Humoral Immune Response in Hamsters. J Vaccines Vaccin 4:185. doi: 10.4172/2157-7560.1000185

Copyright: © 2013 Banihashemi R. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Leptospirosis is an acute infectious disease caused by Leptospira spp. that produces a broad range of health problems mainly in developing world. In several affected countries, a major attempt has been begun to find a potent and effective vaccine. This is while; the available vaccines neither perused immunological memory nor confer cross-protection. Four-week-old male hamsters were subcutaneously inoculated with four-leptospiral vaccine and four-control adjuvant through a triple-injection regiment at fortnightly intervals. Animals were bled through the saphenous vein weekly until the seventh week. We have demonstrated that adjuvant plays a fundamental role in the type and extent of the immune responses raised by leptospiral vaccination. We strongly recommend selection of alum in any formulation of leptospiral vaccine.

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