Development of Novel Anti-aging Drugs
- *Corresponding Author:
- Dr. Fumiaki Uchiumi, Ph.D.
Department of Gene Regulation
Faculty of Pharmaceutical Sciences
Tokyo University of Science, Tokyo University of Science,
2641 Yamazaki, Noda-shi, Chiba-ken 278-8510, Japan
E-mail: [email protected]
Received date: August 25, 2011; Accepted date: August 25, 2011; Published date: August 27, 2011
Citation: Uchiumi F, Oyama T, Ozaki K, Tanuma SI (2011) Development of Novel Anti-aging Drugs. Pharm Anal Acta 2:106e. doi: 10.4172/2153-2435.1000106e
Copyright: © 2011 Uchiumi F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
It has been thought that cellular senescence is regulated by the total amount of damage to chromosomes, including telomeric regions. Another explanation is that cellular senescence is attributed to oxidative stresses mainly generated in mitochondria. At present, several compounds, such as 2-deoxy-D-glucose (2-DG) and trans- Resveratrol (Rsv), are expected to be used as anti-aging drugs for extending life-span. Our previous study indicated that promoter activities of the telomere-maintenance factor-encoding genes are activated by both compounds. The mechanism might be implicated in the concept of hormesis - that the application of low doses of toxic substrates strengthens DNA-repair system. Effective anti-aging drugs could be found by screening compounds that up-regulate expression of the telomere associated genes.