alexa Development of On-Line Solid-Phase Extraction-Liquid Chromatography Coupled with Tandem Mass Spectrometry Method to Quantify Pharmaceutical, Glucuronide Conjugates and Metabolites in Water
ISSN: 2157-7064

Journal of Chromatography & Separation Techniques
Open Access

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Research Article

Development of On-Line Solid-Phase Extraction-Liquid Chromatography Coupled with Tandem Mass Spectrometry Method to Quantify Pharmaceutical, Glucuronide Conjugates and Metabolites in Water

Lea B1, Nicolas C1*, Dominique W1 and Guy R2

1Ecole National de Chimie de Rennes, CNRS, UMR 6226, 11 Allee de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France

2Veolia Eau, Direction Technique Region Ouest, 8 allee Rodolphe Bopierre, 35020 Rennes Cedex 9, France

*Corresponding Author:
Nicolas Cimetiere
Ecole National de Chimie de Rennes, CNRS, UMR 6226, 11 Allee de Beaulieu
CS 50837, 35708 Rennes Cedex 7, France
Tel: +33223238014
E-mail: [email protected]

Received date: September 05, 2016; Accepted date: September 14, 2016; Published date: September 20, 2016

Citation: Lea B, Nicolas C, Dominique W, Guy R (2016) Development of On- Line Solid-Phase Extraction-Liquid Chromatography Coupled with Tandem Mass Spectrometry Method to Quantify Pharmaceutical, Glucuronide Conjugates and Metabolites in Water. J Chromatogr Sep Tech 7:337. doi: 10.4172/2157- 7064.1000337

Copyright: © 2016 Lea B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The present work describes the development of an analytical method, based on automated on-line solid phase extraction followed by ultra high-performance liquid chromatography coupled with tandem mass spectrometry (SPELC- MS/ MS) for the quantification of 37 pharmaceutical residues, covering various therapeutic classes, and some of their main metabolites, in surface and drinking water. A special attention was given to some glucuronide conjuguates and metabolites of active subtances. Multiple Reaction Monitoring (MRM) was chosen and two transitions per compound are monitored (quantification and confirmation transitions). Quantification is performed by standard addition approach to correct matrix effect. The method provides limit of quantification inferior to 20 ng.L-1 for all compounds. The methodology was successfully applied to the analysis of surface water and drinking water of 8 drinking water treatment plant in west of France. The highest drug concentrations in surface water and drinking water were reported for ketoprofen, hydroxyibuprofen, acetaminophen, caffeine and danofloxacin.

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