alexa Dexamethasone Ibuprofen Prodrug Synthesis and Preliminary Kinetic Study
ISSN: 2329-6836

Natural Products Chemistry & Research
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Research Article

Dexamethasone Ibuprofen Prodrug Synthesis and Preliminary Kinetic Study

Amad M Al-Azzawi1,2*, Shaker M Alwan2, Muthanna D Saud2 and Alyaa Ghazi Shaker3
1Pharmaceutical Chemistry Department, College of Pharmaceutical Sciences Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah, UAE, PO Box 11172
2College of Pharmacy, Baghdad University, UAE
3RAK Medical and Health Sciences University, UAE
Corresponding Author : Amad M Al-Azzawi
Pharmaceutical Chemistry Department
College of Pharmaceutical Sciences
Ras Al Khaimah Medical and Health Sciences University
Ras Al Khaimah, UAE, PO Box 11172
E-mail: [email protected]
Received March 18, 2013; Accepted April 27, 2013; Published May 04, 2013
Citation: Al-Azzawi AM, Alwan SM, Saud MD, Shaker AG (2013) Dexamethasone / Ibuprofen Prodrug Synthesis and Preliminary Kinetic Study. Nat Prod Chem Res 1:106. doi: 10.4172/2329-6836.1000106
Copyright: © 2013 Al-Azzawi AM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The synthesis of prodrug dexamethasone conjugated with ibuprofen through a spacer arm amino acid. The potential new prodrug will decrease the gastrointestinal side effects and may change the site of absorption. The synthesis of N-[2-(4-isobutyl-phenyl) propionyl]-glycine (compound 2), which was linked to the Dexamethasone to obtain the final conjugated prodrug (N-[2-(4-isobutyl phenyl) propionyl]-glycine,21-ester with (9-fluoro-11β,17,21 trihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione) (compound 4), detected through UV, IR, and CHN elemental microanalysis. Column chromatography was used for the purification and isolation of compound 4 using gradient elution technique. The kinetic study showed the release of Dexamethasone in different buffers after 10-20 hours using in vitro dissolution. Kinetic study of the synthesized prodrug using High-Pressure Liquid Chromatography (HPLC), Dexamethasone and compound 4 were prepared in different dilutions ranging from 10-70 µg mL-1 in order to determine their specificity, linearity, precision and accuracy.

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