alexa Diabetes Associated Cognitive Decline, is there a Role
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

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Review Article

Diabetes Associated Cognitive Decline, is there a Role for Exercise?

Cajsa Tonoli1,2, Elsa Heyman2, Bart Roelands1,3, Luk Buyse1, Maria Francesca Piacentini1,4, Serge Berthoin2 and Romain Meeusen1*

1Department of Human Physiology and Sports Medicine, Vrije Universiteit Brussel, Belgium and UDSL

2EA4488, Activité Physique-Muscle-Santé, F-59000 Lille, France

3FWO Fonds voor Wetenschappelijk Onderzoek Vlaanderen, Belgium

4Department Human Movement and Sports Science; University of Rome, Rome, Italy

*Corresponding Author:
Romain Meeusen
Department of Human Physiology and Sports Medicine
Faculty of Physical Education and Physical Therapy
Vrije Universiteit Brussel
B-1050 Brussels, Belgium
Tel: (0032) 02 629 22 22
Fax: (0032) 02 629 28 76
E-mail: [email protected]

Received date May 15, 2013; Accepted date June 29, 2013; Published date July 05, 2013

Citation: Tonoli C, Heyman E, Roelands B, Buyse L, Piacentini MF, et al. (2013) Diabetes Associated Cognitive Decline, is there a Role for Exercise?. J Diabetes Metab S10:006. doi:10.4172/2155-6156.S10-006

Copyright: © 2013 Tonoli C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Type 1 Diabetes (T1D) can have a significant impact on brain structure and function. This so-called ‘diabetesassociated cognitive decline’ (DACD) can be attributed to diverse biochemical and neurochemical pathways which are caused by hyperglycaemia, hypoglycaemia, but also by c-peptide and insulin deficiency. Besides the positive effects of exercise on the acute and chronic glycaemic control in T1D patients, a growing number of studies also documented the beneficial influence of exercise on aspects of cognition and performance. Therefore, the purpose of the present narrative review is to discuss the associative aspects between a DACD and its’ proposed mechanisms and the potential beneficial effect of exercise on a DACD.

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