Diabetes Mellitus Type 1, Latent Autoimmune Diabetes of Adults and Hepatitis C Virus: What we Know and what we Need to KnowGrazia Tosone*, Alberto Enrico Maraolo, Giulia Palmiero, Silvia Mascolo and Raffaele Orlando
Department of Clinical Medicine and Surgery – Section of Infectious Diseases, University of Naples Federico II, Italy
- *Corresponding Author:
- Grazia Tosone, MD
Department of Clinical Medicine and Surgery – Section of Infectious Diseases
University of Naples Federico II
Via Sergio Pansini 5, 80131 Naples, Italy
Tel: ++39 0817463082
Fax: ++38 0817463094
E-mail: [email protected]
Received date: August 24, 2013; Accepted date: October 18, 2013; Published date: October 23, 2013
Citation: Tosone G, Maraolo AE, Palmiero G, Mascolo S, Orlando R (2013) Diabetes Mellitus Type 1, Latent Autoimmune Diabetes of Adults and Hepatitis C Virus: What we Know and what we Need to Know. J Diabetes Metab 4:301. doi:10.4172/2155-6156.1000301
Copyright: © 2013 Tosone G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Hepatitis C virus infection and diabetes mellitus are two major public health problems worldwide and the burden of these diseases is expected to increase in the near future. Hepatitis C virus is associated to autoimmune disorders of several organs (e.g. thyroid and kidney) and has recently been reported to be associated also to metabolic disorders including type 2 diabetes mellitus. Biologically, the homologies between the hepatitis C virus polyprotein and the pancreas antigens could underlie a mechanism of molecular mimicry that could lead to autoimmune diabetes (type 1 diabetes mellitus and latent autoimmune diabetes of adults). Here we review the data on the potential relationship between HCV-related chronic liver disease and autoimmune mediated diabetes mellitus.