alexa Diabetic Animal Models with Infectious Diseases: Focus on the Dysfunction of Immune System
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Diabetic Animal Models with Infectious Diseases: Focus on the Dysfunction of Immune System

Li-Tzu Yeh1, Yi-Ping Chuang1, Shyi-Jou Chen2, Chin-Chen Chu3,4 and Huey-Kang Sytwu1*

1Department and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, Taiwan

2Department of Pediatrics, Tri-Service General Hospital, Taiwan

3Department of Anesthesiology, Chi Mei Medical Center, Tainan, Taiwan

4Department of Recreation and Health-Care Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan

*Corresponding Author:
Huey-Kang Sytwu
Department and Graduate Institute of Microbiology and Immunology
National Defense Medical Center, Taiwan
Tel: 02-8792-3100 #18539
Fax: 02-8792-1774
E-mail: [email protected]

Received date: June 28, 2014; Accepted date: August 23, 2014; Published date: August 29, 2014

Citation: Yeh LT, Chuang YP, Chen SJ, Chu CC, Sytwu HK (2014) Diabetic Animal Models with Infectious Diseases: Focus on the Dysfunction of Immune System. J Diabetes Metab 5:417. doi: 10.4172/2155-6156.1000417

Copyright: © 2014 Yeh LT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Diabetes Mellitus (DM) is a metabolic disease that can lead to a variety of complications, such as neuropathy, retinopathy, nephropathy, and cardiovascular disease. Furthermore, pathogen infection accompanied by considerable morbidity and mortality is common among diabetic patients. Increased susceptibility to pathogen infection results from impaired immune responses, such as lower cytokine production and reduced function or migration of immune cells. However, existing clinical data remains controversial because multiple diabetes-related factors such as obesity, hyperglycemia, hyperinsulinemia, and other comorbidities also increase the risk of infection. In recent decades, several animal models have been used to investigate the role played by immune dysfunction in increasing susceptibility to pathogens and related diseases in diabetes. This review focuses on studies that used diabetic animal models to study infectious diseases and summarizes potential mechanisms underlying dysfunction of the immune system in diabetes patients.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords