Diabetic Animal Models with Infectious Diseases: Focus on the Dysfunction of Immune SystemLi-Tzu Yeh1, Yi-Ping Chuang1, Shyi-Jou Chen2, Chin-Chen Chu3,4 and Huey-Kang Sytwu1*
- *Corresponding Author:
- Huey-Kang Sytwu
Department and Graduate Institute of Microbiology and Immunology
National Defense Medical Center, Taiwan
Tel: 02-8792-3100 #18539
E-mail: [email protected]
Received date: June 28, 2014; Accepted date: August 23, 2014; Published date: August 29, 2014
Citation: Yeh LT, Chuang YP, Chen SJ, Chu CC, Sytwu HK (2014) Diabetic Animal Models with Infectious Diseases: Focus on the Dysfunction of Immune System. J Diabetes Metab 5:417. doi: 10.4172/2155-6156.1000417
Copyright: © 2014 Yeh LT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Diabetes Mellitus (DM) is a metabolic disease that can lead to a variety of complications, such as neuropathy, retinopathy, nephropathy, and cardiovascular disease. Furthermore, pathogen infection accompanied by considerable morbidity and mortality is common among diabetic patients. Increased susceptibility to pathogen infection results from impaired immune responses, such as lower cytokine production and reduced function or migration of immune cells. However, existing clinical data remains controversial because multiple diabetes-related factors such as obesity, hyperglycemia, hyperinsulinemia, and other comorbidities also increase the risk of infection. In recent decades, several animal models have been used to investigate the role played by immune dysfunction in increasing susceptibility to pathogens and related diseases in diabetes. This review focuses on studies that used diabetic animal models to study infectious diseases and summarizes potential mechanisms underlying dysfunction of the immune system in diabetes patients.