alexa Diabetic Feet Scald with Popliteal Artery Ligation - A
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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Research Article

Diabetic Feet Scald with Popliteal Artery Ligation - A New Study Rat Model, Represent Human Diabetic Foot Ulceration

Huimin Han1*, Yandong Liu1, Abu Taiub Mohammed Mohiuddin Chowdhury2 and Shahid Alam3

1Institute of Endocrinology, The 4th Daqing City Hospital, Daqing, China

2Department of Digestive disease-II, First Affiliated Hospital of Jiamusi University, China

3Department of Vascular Surgery, First Affiliated Hospital of Jiamusi University, China

Corresponding Author:
Huimin Han
Institute of Endocrinology
The 4th Daqing City Hospital, Daqing, China
Tel: 008801817711079
E-mail: [email protected]

Received Date: December 04, 2014; Accepted Date: December 18, 2014; Published Date: December 26, 2014

Citation: Han H, Liu Y, Chowdhury ATMM, Alam S (2015) Diabetic Feet Scald with Popliteal Artery Ligation - A New Study Rat Model, Represent Human Diabetic Foot Ulceration. J Mol Genet Med 9:149. doi: 10.4172/1747-0862.1000149

Copyright: © 2014 Han H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

 

Abstract

Diabetes mellitus is a potent metabolic disorder of this time. Due to the progression of disease itself and along with the collateral damages by its various complications this is being considered as one of the greatest threat to patient’s well-being & status. During recent years the prevalence of ulceration in diabetic patients especially foot ulcer has dramatically increased, causing tremendous negative impact over the patient. But unfortunately, there is no reliable animal model that resembles human diabetic foot ulcer, thus the study of ulcer healing under conditions of “diabetes mellitus” remains a challenge. In this literature, we describe a new approach to establish an experimental model that accurately resembles human diabetic foot ulceration. This new model will likely provide a superior way to study diabetic foot ulceration. The objective of this study was aimed to investigate and compare the established “rat models of diabetic foot ulceration” in order to determine the most suitable option that represents the similar state of the disease in human. Diabetic sample were prepared by using Wistar rats and they were divided in to four groups - A. Diabetic foot scalded group, B. bilateral popliteal artery ligation group, C. Diabetic foot scalded plus popliteal artery ligation group, D. Disease control group. After a period of thirty days the rats were assessed by- nail discoloration, degree of muscular atrophy, size of ulcer, purulent secretions and presence granulation tissue in the wound bed. Our study concludes that- “diabetic foot scalded plus popliteal artery ligation group” rats most closely resemble the symptoms of the human diabetic foot.

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