alexa Diabetic ketoacidosis due to Simultaneous Acute-Onset T
ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Case Report

Diabetic ketoacidosis due to Simultaneous Acute-Onset Type 1 Diabetes and Graves Disease

Chikaaki Kobashi1, Emiri Muranaka1, Kanako Motoyoshi1, Yukihiro Satou1, Tadashi Ikeda2, Kouichi Shigeta1 and Masaharu Urakaze1*

1Kamiichi General Hospital, Medicine and Diabetic Center, Kamiichi-machi, Toyama, Japan

2Ikeda Medical Clinic, Kamiichi-machi, Toyama, Japan

*Corresponding Author:
Masaharu Urakaze
Kamiichi General Hospital
Medicine and Diabetic Center
Kamiichi-machi, Toyama, Japan
Tel: 81764721212
E-mail: [email protected]

Received May 17, 2016; Accepted May 23, 2016; Published May 28, 2016

Citation: Kobashi C, Muranaka E, Motoyoshi K, Satou Y, Ikeda T, et al. (2016) Diabetic Ketoacidosis due to Simultaneous Acute-onset Type 1 Diabetes and Graves Disease. J Diabetes Metab 7:671. doi:10.4172/2155-6156.1000671

Copyright: © 2016 Kobashi C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



An 18-year old Japanese woman with thirst, weight loss and palpitations for a few weeks’ duration was admitted. Her diagnosis was diabetic ketoacidosis with acute-onset type 1 diabetes (T1D) and Graves’ disease (GD) (autoimmune polyglandular syndrome type 3 variant; APS3v). She was treated with intensification therapy with insulin and anti-thyroid drugs. Human leukocyte antigen testing revealed that her HLA type was HLA- DRB1*08:02-DQA1*03:01-DQB1*03:02 haplotype, which was vulnerable not only to APS3v, but also to both acute-onset T1D and GD. This genetic factor probably contributes to the simultaneous occurrence of T1D and GD.


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