alexa Diagnosis of Bloodstream Infections by Mass Spectrometry: Present and Future | OMICS International | Abstract
ISSN: 2469-9861

Mass Spectrometry & Purification Techniques
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Review Article

Diagnosis of Bloodstream Infections by Mass Spectrometry: Present and Future

Walter Florio1, Paola Morici1, Cosmeri Rizzato2, Simona Barnini3, Arianna Tavanti2 and Antonella Lupetti1*

1Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, Università di Pisa, via San Zeno 37-39, 56127 Pisa, Italy

2Dipartimento di Biologia, Università di Pisa, via San Zeno 37-39, 56127 Pisa, Italy

3Azienda Ospedaliero-Universitaria Pisana, via Paradisa 2, 56124 Pisa, Italy

*Corresponding Author:
Antonella Lupetti
Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia
Università di Pisa, Via San Zeno 37-39, 56127 Pisa, Italy
Tel: +39-050-2213722
E-mail: [email protected]

Received date: September 29, 2015; Accepted date: October 04, 2015; Published date: October 11, 2015

Citation: Florio W, Morici P, Rizzato C, Barnini S, Tavanti A, et al. (2015) Diagnosis of Bloodstream Infections by Mass Spectrometry: Present and Future. Mass Spectrom Open Access 1:106. doi:10.4172/2469-9861.1000106

Copyright: © 2015 Florio W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Rapid identification and antimicrobial susceptibility testing of the causative agent(s) of bloodstream infections may impact on the clinical outcome of patients, which is directly related to the prompt administration of an effective antimicrobial therapy. Empirical antimicrobial therapy is chosen on the basis of clinical and epidemiological data and it is administered immediately after blood sampling but, in a significant number of cases, it has to be streamlined on the basis of the microbiological report. Rapid identification has a clinically relevant impact on the timely selection of an appropriate antimicrobial therapy, especially in low-prevalence areas for antimicrobial resistance. Recently, the identification process of isolated bacteria has been revolutionized by the introduction of mass spectrometry (MS), particularly MALDI-TOF, in clinical microbiology laboratories. Furthermore, MALDI-TOF is one of the most promising techniques for the identification of bacterial and fungal infectious agents directly from positive blood cultures and a potentially useful tool for the detection of antimicrobial resistance, specifically that conferred by β-lactamases. Although blood culture remains, at present, the gold standard to diagnose bloodstream infections, newly developed MALDI-TOF methods are useful adjunctive tests to fasten the diagnostic process and further increase the diagnostic yield.

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