alexa Diagnostic Performance of 18F-FDG PET or PET-CT in Mult
ISSN: 2155-9619

Journal of Nuclear Medicine & Radiation Therapy
Open Access

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Review Article

Diagnostic Performance of 18F-FDG PET or PET-CT in Multiple Myeloma: A Systematic Review and Meta-analysis

Xue Liu1, Jia Liang2, Jun-Hong Li1, Qi-Lian Ran2, Liang-Sen Liu1, Li Jiang3, Jian-Xiong Long4, Yue-Ming Jiang4 and Zhi-Xiao Wei1*

1Department of Nuclear Medicine and Radiotherapy, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

2School of Basic Medicine and Public Health of Guangxi Medical University, Nanning, Guangxi, China

3Department of Radiotherapy, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

4Department of Public Health of Guangxi Medical University, Nanning, Guangxi, China

*Corresponding Author:
Zhi-Xiao Wei
Department of Nuclear Medicine and Radiotherapy
First Affiliated Hospital of Guangxi Medical University
Nanning, Guangxi, China
Tel: +86-771-5328803
Fax: +86-771-5330700
E-mail: [email protected]

Received date: January 23, 2016 Accepted date: February 27, 2016 Published date: March 05, 2016

Citation: Xue L, Jia L, Jun-Hong L, Qi-Lian R, Liang-Sen L, et al. (2016) Diagnostic Performance of 18F-FDG PET or PET-CT in Multiple Myeloma: A Systematic Review and Meta-analysis. J Nucl Med Radiat Ther 7:283. doi: 10.4172/2155-9619.1000283

Copyright: © 2016 Liu X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License; which permits unrestricted use; distribution; and reproduction in any medium; provided the original author and source are credited.

 

Abstract

Objectives: Conduct a systematic review and meta-analysis to assess the diagnostic performance of 18Ffluorodeoxyglucose positron emission tomography (18F-FDG PET) or PET-computed tomography (PET-CT) in multiple myeloma (MM). Methods: A comprehensive literature search about studies that published till July 2015 was performed. Methodological quality of each study was assessed. The meta-regression and subgroup analysis was applied to assess the heterogeneity of between-study. A meta-analysis was used to state sensitivity, specificity, diagnostic odds ratio (DOR), area under the curve (AUC), summary receiver operating characteristic (SROC) curve and Ǫ* indexes with statistical software. Results: Eleven studies met the inclusion criteria in this meta-analysis, which comprise a total of 492 patients. The pooled sensitivity and specificity of 18F-FDG PET or PET-CT in multiple myeloma were 0.870 (95% CI, 0.825-0.907), 0.937 (95% CI, 0.892-0.967), and the AUC and the Ǫ* index were 0.9332, 0.869, respectively. The pooled sensitivity and specificity of PET in multiple myeloma were 0.94495% CI, 0.887-0.977) and 0.990 (95% CI, 0.947-1.000), and the AUC and the Ǫ* index were 0.98, 0.95, respectively. The pooled sensitivity and specificity for PET-CT in multiple myeloma were 0.813 (95% CI, 0.743-0.870) and 0.875 (95% CI, 0.787-0.936), and the AUC and the Ǫ* index were 0.88, 0.82, respectively. The funnel plots suggested the publication bias may exist. Conclusions: The whole-body 18F-FDG PET or PET-CT were imaging methods with high accuracy in differential diagnosis of multiple myeloma patients.

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