Diagnostic Performance of 18F-FDG PET or PET-CT in Multiple Myeloma: A Systematic Review and Meta-analysis
- *Corresponding Author:
- Zhi-Xiao Wei
Department of Nuclear Medicine and Radiotherapy
First Affiliated Hospital of Guangxi Medical University
Nanning, Guangxi, China
E-mail: [email protected]
Received date: January 23, 2016 Accepted date: February 27, 2016 Published date: March 05, 2016
Citation: Xue L, Jia L, Jun-Hong L, Qi-Lian R, Liang-Sen L, et al. (2016) Diagnostic Performance of 18F-FDG PET or PET-CT in Multiple Myeloma: A Systematic Review and Meta-analysis. J Nucl Med Radiat Ther 7:283. doi: 10.4172/2155-9619.1000283
Copyright: © 2016 Liu X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License; which permits unrestricted use; distribution; and reproduction in any medium; provided the original author and source are credited.
Objectives: Conduct a systematic review and meta-analysis to assess the diagnostic performance of 18Ffluorodeoxyglucose positron emission tomography (18F-FDG PET) or PET-computed tomography (PET-CT) in multiple myeloma (MM). Methods: A comprehensive literature search about studies that published till July 2015 was performed. Methodological quality of each study was assessed. The meta-regression and subgroup analysis was applied to assess the heterogeneity of between-study. A meta-analysis was used to state sensitivity, specificity, diagnostic odds ratio (DOR), area under the curve (AUC), summary receiver operating characteristic (SROC) curve and ÃÂª* indexes with statistical software. Results: Eleven studies met the inclusion criteria in this meta-analysis, which comprise a total of 492 patients. The pooled sensitivity and specificity of 18F-FDG PET or PET-CT in multiple myeloma were 0.870 (95% CI, 0.825-0.907), 0.937 (95% CI, 0.892-0.967), and the AUC and the ÃÂª* index were 0.9332, 0.869, respectively. The pooled sensitivity and specificity of PET in multiple myeloma were 0.94495% CI, 0.887-0.977) and 0.990 (95% CI, 0.947-1.000), and the AUC and the ÃÂª* index were 0.98, 0.95, respectively. The pooled sensitivity and specificity for PET-CT in multiple myeloma were 0.813 (95% CI, 0.743-0.870) and 0.875 (95% CI, 0.787-0.936), and the AUC and the ÃÂª* index were 0.88, 0.82, respectively. The funnel plots suggested the publication bias may exist. Conclusions: The whole-body 18F-FDG PET or PET-CT were imaging methods with high accuracy in differential diagnosis of multiple myeloma patients.