alexa Diagnostic Procedures and Follow Up of Macular Microstr
ISSN: 2157-7099

Journal of Cytology & Histology
Open Access

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Research Article

Diagnostic Procedures and Follow Up of Macular Microstructural Changes in Patients with Uveitis as Seen on Optical Coherence Tomography

Jelena Paovic1*, Predrag Paovic1, Anka Stanojevic Paovic2 and Vojislav Sredovic3

1Department of Ophthalmology, University Clinical Center, Pasterova 2, 11000 Belgrade, Serbia

2Uvea Center, Center for Diagnosis and Treatment of Eye Diseases, Kneza od Semberije 14, 11000 Belgrade, Serbia

3Primary Health Care Center, Jove Negusevica 5, 22419 Pecinci, Serbia

*Corresponding Author:
Jelena Paovic
Department of Ophthalmology
University Clinical Center
Pasterova 2, 11000 Belgrade, Serbia
Tel: +38163245552
E-mail: [email protected]

Received Date: October 11, 2013; Accepted Date: December 30, 2013; Published Date: January 01, 2014

Citation: Paovic J, Paovic P, Paovic AS, Sredovic V (2013) Diagnostic Procedures and Follow Up of Macular Microstructural Changes in Patients with Uveitis as Seen on Optical Coherence Tomography. J Cytol Histol 5:211. doi: 10.4172/2157-7099.1000211

Copyright: © 2014 Paovic J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The aim of this study was to show how optical coherence tomography (OCT) can provide means for assessing macula and the optic disc, and so can be used to diagnose and follow micro-structural, macular, changes (epiretinal membranes; macular edema; lamellar hole and discontinuity of inner/outer segment line), that occur as complications of a disease (i.e. uveitis). It is a non invasive, non contact method that provides cross-sectional images of retina and its substructures in a real-time mode. High definition cross-sectional images obtained by a commercially available OCT are attained at 1-15 μm and can provide detailed pictures from deep within the retina. Seeing that OCT can be repeated numerous times it is useful for practitioners that need to follow treatment effects and progression of the disease. Spectral-Domain OCT was used to diagnose and follow macular changes in patients with uveitis (intermediate and posterior) and retinal vasculitis. OCT showed an epiretinal membrane (ERM) as intense back-reflective layer on the inner retinal surface. Via this method thickness measurements of ERM as well as the degree of inner retinal surface attachment (focal or diffused) were acquired and precisely defined. OCT showed macular edema as retinal layering followed by presence of intraretinal cavities and absence of back-reflection. It provided means of measuring thickness, localization, as well as size of intraretinal cysts during the evolution of macular edema (ME), and so was utilized in analysis of various factors such as progression of ERM; presence of ME; surface roughness; changes of thickness and layer configuration of retinal tissue. OCT macular scan provides precise and quick diagnosis of delicate microstructural retinal changes in high definition that can’t be obtained during classical clinical examination. Progression of disease, changes and treatment effects, followed via OCT, are of great importance in clinical practice.

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