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ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

Diagnostic, Prognostic and Theranostic Biomarkers for Rheumatoid Arthritis

Cathy M McGeough* and Anthony J Bjourson
Biomedical Sciences Research Institute (BMSRI), University of Ulster, Cromore road, Coleraine, Co Londonderry Northern Ireland, UK
Corresponding Author : Cathy M McGeough
BMSRI, University of Ulster
Cromore road, Coleraine
Co Londonderry Northern Ireland, BT52 1SA, UK
Tel: +44 28701 24674
E-mail: [email protected]
Received May 30, 2012; Accepted June 15, 2012; Published June 28, 2012
Citation: McGeough CM, Bjourson AJ (2012) Diagnostic, Prognostic and Theranostic Genetic Biomarkers for Rheumatoid Arthritis. J Clin Cell Immunol S6:002. doi:10.4172/2155-9899.S6-002
Copyright: © 2011 McGeough CM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The identification and adoption of diagnostic and prognostic biomarkers for rheumatoid arthritis has informed and improved the clinical management of this disease. With the advent of biologic treatments such as anti-Tumour Necrosis Factor (anti-TNF) therapy, achieving disease remission has become a realistic endpoint for clinicians. The life-changing efficacy of these therapies however is restricted to the 60-70% of patients who respond. The immune reaction to anti-inflammatory therapy is thought to be influenced by many genes which cumulatively contribute to a threshold for response. There is an inherent clinical need to provide theranostic biomarkers which could determine treatment outcome. The current role of genetic biomarkers in diagnosis, prognosis and predicting response to anti-TNF therapy are discussed.

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