alexa Dialyzability of Surfactants Commonly Used in Pesticide Formulations
ISSN: 2161-0495

Journal of Clinical Toxicology
Open Access

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Research Article

Dialyzability of Surfactants Commonly Used in Pesticide Formulations

Sun-Hyo Lee1, Su-Yeon Park2, Soohyun Kim3, Hyo-Wook Gil1 and Sae-Yong Hong1*

1Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Korea

2Biostatistics, Soonchunhyang University Hospital, Cheonan, Korea

3BioFabula, Daejeon, Korea

*Corresponding Author:
Sae-Yong Hong
Department of Internal Medicine
Soonchunhyang University Cheonan Hospital
Soonchunhyang 6 Gil, Dongnam-Gu
Cheonan 330-721, Korea
Tel: +82 41 570 3682
Fax: +82 41 574 5762
E-mail: [email protected]

Received date: March 03, 2016; Accepted date: May 05, 2016; Published date: May 12, 2016

Citation: Lee SH, Park SY, Kim S, Gil HW, Hong SY (2016) Dialyzability of Surfactants Commonly Used in Pesticide Formulations. J Clin Toxicol 6:303. doi: 10.4172/2161-0495.1000303

Copyright: © 2016 Lee SH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objective: This study aimed to determine the dialyzability of common pesticide surfactants.
Methods: Hemodialysis and hemoperfusion were performed for three surfactants-sodium
dodecylbenzenesulfonate, lignosulfonic acid sodium, and naphthalenesulfonic acid polymer with formaldehyde-with
buffer solutions (2 L) containing 0.2% surfactant with or without bovine serum albumin (3.0 g/dL).
Results: The dialyzability of sodium dodecylbenzenesulfonate during hemodialysis was high and increased with
ultrafiltration. The final reduction rates of naphthalene sulfonic acid polymer with formaldehyde and sodium
dodecylbenzenesulfonate in bovine serum albumin were higher for hemoperfusion (25.8% and 26.8%, respectively)
than for hemodialysis (8.2% and 0%, respectively). In contrast, the final reduction rate of lignosulfonic acid sodium in
bovine serum albumin was higher for hemodialysis (37.5%) than for hemoperfusion (13.2%).
Conclusion: Our results suggest that extracorporeal elimination may be an effective treatment modality in
patients who ingested surfactant mixed pesticides. However, the dialysis method looks likely to be tailored to each
surfactant, based on its dialyzability.


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