alexa Diameter of a Hollow Center in Cylindrical Hydroxyapatite Scaffold for Hard Tissue Formation

Bioceramics Development and Applications
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Research Article

Diameter of a Hollow Center in Cylindrical Hydroxyapatite Scaffold for Hard Tissue Formation

N. Tsuji1*, M. Yoshikawa1,2, H. Hayashi1, and H. Ohgushi2

1Department of Endodontics, Osaka Dental University, Osaka 540-0008, Japan

2Tissue Engineering Research Group, Research Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology, Hyogo 661-0974, Japan

*Corresponding Author:
N. Tsuji
Department of Endodontics
Osaka Dental University
Osaka 540-0008, Japan
E-mail: [email protected]

Received date: November 11, 2010; Accepted date: December 02, 2010



The purpose of this study was to obtain an appropriate geometry of porous hydroxyapatite scaffold for hard tissue formation in most of the pores. Porous cylindrical hydroxyapatite structures with a hollow center as a scaffold were manufactured. The diameter of a hollow center was 2 or 3 mm. Bone marrow cells were obtained from bone shafts of femora of 6-week-old male Fischer 344 rats. The cell/hydroxyapatite composite scaffolds were implanted in dorsal subcutis of 7-week-old male Fischer 344 rats. They were removed 8 weeks postoperatively. Serially sectioned paraffin specimens were made and observed histologically. The ratio of pores including hard tissue to the number of total pores per a square centimeter of the cross-sectional area in the scaffolds was calculated. In the scaffold with a hollow center measuring 2mm in diameter, a new hard tissue formation was observed near the superficies and the number of pores including hard tissue was 260.6 ± 60.8/cm2. In the scaffold with a hollow center measuring 3mm in diameter, new hard tissue was observed between superficies and the wall of the hollow center. The number of pores including hard tissue was 589.6 ± 73.3/cm2.


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