Dietary Flaxseed in Non-Small Cell Lung Cancer Patients Receiving ChemoradiationBerman Abigail T1, Turowski Jason2, Mick Rosemarie3, Cengel Keith1, Farnese Nicole1, Basel-Brown Lisa1, Mesaros Clementina4, Blair Ian4, Lawson James4, Christofidou-Solomidou Melpo3, Lee James3 and Rengan Ramesh1*
- *Corresponding Author:
- Ramesh Rengan, MD, PhD
Department of Radiation Oncology
University of Washington, USA
E-mail: [email protected]
Received date: April 04, 2013; Accepted date: August 28, 2013; Published date: August 30, 2013
Citation: Berman Abigail T, Jason T, Rosemarie M, Keith C, Nicole F, Lisa BB, et al. (2013) Dietary Flaxseed in Non-Small Cell Lung Cancer Patients Receiving Chemoradiation J Pulm Respir Med 3:154. doi: 10.4172/2161-105X.1000154
Copyright: © 2013 Berman Abigail T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Purpose: The standard of care in Locally-Advanced Non-Small Cell Lung Cancer (LA-NSCLC) is chemotherapy and radiation; however, Radiation-Induced Lung Injury (RILI), which may be prevented by the anti-inflammatory and anti-oxidant properties of Flaxseed (FS), impedes its maximum benefit.
Materials and Methods: Patients with LA-NSCLC requiring definitive RT were randomized to one FS or control muffin daily from start to 2 weeks after RT. Blood and urine were collected to quantify plasma FS metabolites, Enterodione (ED) and Enterolactone (EL), and urinary oxidative stress biomarkers, 8, 12-iso-iPF2a-VI (isoprostane) and 8-oxo-7,8-dihydro-2’deoxyguanosine (8-oxo-dGuo). Tolerability was defined as consuming ≥ 75% of the intended muffins and no ≥ grade 3 gastrointestinal toxicities.
Results: Fourteen patients (control,7; FS,7) were enrolled. The tolerability rates were 42.9 versus 71.4% (p=0.59) for FS and control, respectively. Mean percentages of intended number of muffins consumed were 37% versus 73% (p=0.12). ED and EL increased at onset of FS and decreased with discontinuation, confirming bioavailability. Isoprostane and 8-oxo-dGuo were detectable. There was a trend towards decreased rates of pneumonitis in FS.
Conclusions: This is the first study to report FS bioavailability and quantify oxidative stress markers in NSCLC patients. FS in the administered muffin formulation did not meet tolerability criteria. Given the promising mechanism of FS as a radioprotectant, further investigations should focus on the optimal method for administration of FS.