Difference in Absolute CD4+ Count According to CD4 Percentage between Asian and Caucasian HIV-Infected Patients
- *Corresponding Author:
- Dr. Amit C. Achhra
National Centre in HIV Epidemiology and Clinical Research
The University of New South Wales
Cliffbrook Campus, 45 Beach Street
Coogee, NSW 2034, Sydney, Australia
Tel: +612 9385 0900
Fax: +612 9385 0920
E-mail: [email protected]
Received Date: August 12, 2010; Accepted Date: October 08, 2010; Published Date: October 08, 2010
Citation: Achhra AC, Zhou J, Dabis F, Pujari S, Thiebaut R, et al. (2010) Difference in Absolute CD4+ Count According to CD4 Percentage between Asian and Caucasian HIV-Infected Patients. J AIDS Clinic Res 1:101. doi:10.4172/2155-6113.1000101
Copyright: © 2010 Achhra AC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
We compared the absolute CD4+ count, at different CD4+ percentages (CD4%), between Asian (n=442) and Caucasian (n=674) untreated HIV-infected individuals, using linear regression methods. At any given CD4%, Asians had lower CD4+ count than Caucasians (p=0.001). The difference varied from 38.9 cells/mm3 (95% CI: 3.3-74.5 cells/ mm3) at CD4% of 15% to 108.7 cells/mm3 (95% CI: 42.5-174.9 cells/mm3) at CD4% of 40%. The impact of these differences on prognosis is uncertain, but it may be that the prognostic thresholds for CD4+ count used in Caucasian populations are inappropriate in Asian populations.