alexa Different Biomarkers Address Different Colorectal Cancer Stem Cell Populations: Who's the Killer?
ISSN-2155-9929

Journal of Molecular Biomarkers & Diagnosis
Open Access

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Research Article

Different Biomarkers Address Different Colorectal Cancer Stem Cell Populations: Who's the Killer?

Gennaro Galizia1*, Marica Gemei1, Margherita Pinto1, Anna Zamboli1, Andrea Mabilia1, Annamaria Auricchio1, Michele Orditura2, Ferdinando De Vita2, Eva Lieto2 and Ciro Romano3

1Division of Surgical Oncology, Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, Naples, Italy

2Division of Medical Oncology, Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, Naples, Italy

3Division of Internal Medicine, Allergy and Clinical Immunology, Department of Medicine, Second University of Naples School of Medicine, Naples, Italy

*Corresponding Author:
Gennaro Galizia
Second University of Naples School of Medicine
Department of Clinical and Experimental Medicine and Surgery
II Policlinico, Edificio 17, 580131 Naples, Italy
Tel: +39-081-566-6613
Fax: +39-081-566-6817
E-mail: [email protected]

Received date: June 01, 2012; Accepted date: June 10, 2012; Published date: July 12, 2012

Citation: Galizia G, Gemei M, Pinto M, Zamboli A, Mabilia A, et al. (2012) Different Biomarkers Address Different Colorectal Cancer Stem Cell Populations: Who’s the Killer? J Mol Biomarkers Diagn S8:004. doi:10.4172/2155-9929.S8-004

Copyright: © 2012 Galizia G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

 

Abstract

Recent findings suggested the presence in several cancers, comprising colorectal malignancies, of a small subset of tumor-initiating cells, or cancer stem cells. So the isolation and characterization of tumorigenic colorectal cancer cells was extremely important for the development of new diagnostic and therapeutic procedures. Even if a defined and universally approved phenotype of colorectal cancer stem cells has not been defined yet, several markers have been reported able to isolate cancer stem-like cells. For the majority of these markers, it has not been associated a clear function but more of them seem to be involved in colon cancer stem cell maintenance, survival and proliferation through well known pathways such as the Wnt-β-catenin pathway whose activity has been demonstrated to define colorectal cancer stem cells. Even if the knowledge on colorectal cancer stem cell “functioning” is still little detailed and elusive, the importance to develop new therapeutic strategies that precisely target colorectal cancer stem cells prompted researchers to test different approaches to this aim. We summarize here the phenotypic and functional characteristics associated with colon cancer stem cells along with the approaches experimented to selectively target and kill these cancer cells. We also reviewed innovative approaches targeting colorectal cancer stem cells based on new delivery systems to precisely kill them or also on the combination of conventional therapies with functional dietary elements.

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