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ISSN: 2168-9547

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Research Article

Different Types of Transgene Silencing in Animals: A Natural Foundation for RNAi Technology

Sampada Sontakke1, Kishan K Khetan1, Subhodeep Banerjee1, Tanmoy Mondal2, Jagamohan Chhatai1, Manika Pal-Bhadra2 and Utpal Bhadra1*

1Functional Genomics and Gene Silencing Group, Centre For Cellular and Molecular Biology, Hyderabad, India

2Centre for Chemical Biology, Indian Institute for Chemical Technology, Hyderabad, India-500007, India

*Corresponding Author:
Utpal Bhadra
Centre for Cellular and Molecular Biology
Uppal Road, Hyderabad-500 007, India
Tel: +91 40 27192513
Fax: +91 40 27160591
E-mail: [email protected]

Received date: September 07, 2015; Accepted date: September 23, 2015; Published date: September 30, 2015

Citation: Sontakke S, Khetan KK, Banerjee S, Mondal T, Chhatai J, et al. (2015) Different Types of Transgene Silencing in Animals: A Natural Foundation for RNAi Technology. Mol Biol 4:137. doi:10.4172/2168-9547.1000137

Copyright: © 2015 Sontakke S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The RNAi technology is a revolutionarized and powerful mechanism for in built alternate cell defence of an organism. The foreign DNA intruders form double stranded RNA intermediate during their propagation, which further cleaved in small antisense RNA by the action of dicing enzyme Dicer and further coupled with the complementary RNA for nucleation. Now a days lot more transgene were developed that involved frequently different silencing tricks, in extreme cases threshold induced silencing, DNA elimination etc. In few organisms the hall mark of silencing are involved in unpaired DNA silencing in somatic cells. The simple co-suppression events and double stranded mediated RNA degradation creates a new technology RNAI for a readymade knock down methods, However beyond limiting unfold silencing strategies of different transgenes in transcriptional silencing and RNAi technology has imported connection that are subject to answer in the review. We imagine new more powerful technology may generate for readymade activation or silencing based on the recently invented different types of transgene silencing.

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