alexa Differential Diagnosis of Non-Segmental Consolidations
ISSN: 2161-105X

Journal of Pulmonary & Respiratory Medicine
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Review Article

Differential Diagnosis of Non-Segmental Consolidations

Attiya Haroon1*, Futoshi Higa1, Shusaku Haranaga1, Satomi Yara1, Masao Tateyama1, Haley L Cash1, Takashi Ogura2 and Jiro Fujita1

1Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases (First Department of Internal Medicine), Faculty of Medicine, University of the Ryukyus, Okinawa, Japan

2Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Kanagawa, Japan

*Corresponding Author:
Attiya Haroon
Department of Infectious, Respiratory, and Digestive Medicine
Control and Prevention of Infectious Diseases
(First Department of Internal Medicine)
Faculty of Medicine, University of the Ryukyus
207 Uehara, Nishihara-cho, Okinawa, 903-0215, Japan
Tel: +81-98-895-1142
Fax: +81-98-895-1414
E-mail: [email protected]

Received date: January 31, 2013; Accepted date: April 22, 2013; Published date: April 24, 2013

Citation: Haroon A, Higa F, Haranaga S, Yara S, Tateyama M, et al. (2013) Differential Diagnosis of Non-Segmental Consolidations. J Pulmon Resp Med S8:001. doi:10.4172/2161-105X.S8-001

Copyright: © 2013 Haroon A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Consolidation and Ground-Glass Opacities (GGO) are common findings on chest Computed Tomographic (CT) scans. Consolidation and GGO can be divided into segmental, non-segmental and interstitial pneumonia types based upon distribution pattern. The aim of this review is to highlight the importance of the non-segmental distribution pattern, and to explain its relevancy in various conditions. Non-segmental distribution pattern presents as lobar pneumonia histologically, whereas segmental distribution appears as bronchopneumonia. The different diagnoses that can be derived from non-segmental distribution consist of infectious pneumonias caused by S. pneumoniae, K. pneumoniae and L. pneumophila, Chlamydophila psittaci, M. pneumoniae, measles, viral pneumonia and tuberculosis, as well as non-infectious inflammatory diseases including Cryptogenic Organizing Pneumonia (COP), Chronic Eosinophilic Pneumonia (CEP) and Pulmonary Alveolar Proteinosis (PAP), and other conditions including Anti-Neutrophil Cytoplasmic Antibody (ANCA) related pulmonary hemorrhage and Bronchoalveolar Carcinoma (BAC). A detailed analysis and correlation of non-segmental distribution with other CT findings (e.g., ground-glass opacity, interlobular septal thickening, fibrosis, pleural effusion, air trapping, nodular lesions, and air bronchiologram and air bronchogram) can facilitate the accurate diagnosis of these respiratory diseases. Specifically of interest is L. pneumophila infection, which first presents as bronchopneumonia but later converts into lobar pneumonia. The mechanism behind this conversion involves inflammatory exudates that can pass through Kohn’s pores and Lambert’s channel during L. pneumophila infection. Therefore, L. pneumophila pneumonia pattern first presents as segmental at the start of infection and after 2 weeks or more converts into non-segmental type. Overall, this review demonstrates that the nonsegmental distribution pattern can be very valuable in making respiratory disease diagnosis.

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