Differential Role of AMP-Activated Protein Kinase in Brown and White Adipose Tissue Components and Its Consequences in Metabolic DiseasesMonireh Dashty*
Department of Cell Biology, University Medical Center Groningen, University of Groningen, A Deusinglaan 1, NL-9713 AV Groningen, The Netherlands
- *Corresponding Author:
- Monireh Dashty
Department of Cell Biology (Immunology), University Medical Center Groningen
University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen
Tel: +31 (0) 50 3632536
Fax: +31 (0) 50 3632522
E-mail: [email protected]
Received date: April 26, 2014; Accepted date: July 25, 2014; Published date: August 03, 2014
Citation: Dashty M (2014) Nutrient Signaling in Adipose Tissue and its Consequences for Metabolic Disease. J Diabetes Metab 5: 406. doi: 10.4172/2155-6156.1000406
Copyright: © 2014 Dashty M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The LKB1/AMPK/TSC/mTORC1 cassette constitutes a canonical signaling pathway that integrates the metabolic and nutrient status of the cell for regulation of cell growth and survival and would thus be expected to be of critical importance in adipose tissue; the main organ in the body dealing with energy homeostasis. Indeed it has now become clear that changes in AMPK activity, and to a lesser extent in Akt/PKB, guides almost every process in this tissue and that modulation of the activity of the nutrient signaling cassette offers a wide range of option to deal with metabolic diseases. Here I review the current body of biomedical literature on nutrient signaling in adipose tissue and show that although the effects involved are highly cell type specific in general, pharmacological AMPK activation seems the way forward losses in adiposity. It should thus prove exceedingly interesting to watch the results of clinical trial in obese subjects treated with AMPK analogues.