Differing Behavior of Plasma Pentraxin3 and High-Sensitive CRP at the Very Onset of Myocardial Infarction with ST-segment ElevationTetsuo Yamasaki, Tomomi Koizumi*, Tohru Tamaki, Atsushi Sakamoto, Toshihiko Kikutani, Koichi Sano, Toshihiro Muramatsu, Kazuo Matsumoto, Nobuyuki Komiyama and Shigeyuki Nishimura
Department of Cardiovascular Medicine, Saitama International Medical Center, Saitama Medical University, Hidaka, Japan
- *Corresponding Author:
- Tomomi Koizumi, MD, PhD, FACC
Associate Professor of Medicine Division of Cardiovascular Medicine
Saitama International Medical Center
Saitama Medical University
1397-1 Yamane, Hidaka
Saitama 350-1298, Japan
Tel: +81- 42-984-4531
Fax: +81- 42-984-4741
E-mail: [email protected]
Received July 05, 2013; Accepted July 25, 2013; Published July 27, 2013
Citation: Yamasaki T, Koizumi T, Tamaki T, Sakamoto A, Kikutani T, et al. (2013) Differing Behavior of Plasma Pentraxin3 and High-Sensitive CRP at the Very Onset of Myocardial Infarction with ST-Segment Elevation. Angiol 1:108. doi: 10.4172/2329-9495.1000108
Copyright: © 2013 Yamasaki T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Although pentraxin3 (PTX3) has been reported as marker of more directly reflect the vascular inflammatory status than short pentraxin including high-sensitive CRP (hs-CRP), detailed difference in blood levels between PTX3 and hs-CRP at the onset of ST-segment elevation myocardial infarction (STEMI) are not fully investigated. Blood levels of pentraxins (PTX3 and hs-CRP) in 20 patients with early arrival of STEMI (2.9 ± 2.2 hours after onset) were measured at baseline, 24, 48, 72 and 120 hours after primary percutaneous coronary intervention (PCI). Also, the blood levels in infarct-related artery (IRA) were measured by thrombus aspiration during PCI. Samples of control (not myocardial infarction) with normal coronary artery (n=10) were drawn from both coronary and peripheral arteries during diagnostic coronary angiography. At baseline, the levels of PTX3 in both femoral and coronary artery in STEMI were significantly higher than those in control, but the hs-CRP did not different between STEMI and control. The level of both PTX3 and hs-CRP did not different between femoral artery and IRA in STEMI patients at baseline. Systemic level of PTX3 peaked 24 hours (p=0.01) followed by the hs-CRP that peaked 48 hours (p<0.01) after the PCI. PTX3 had appeared earlier than hs-CRP in the systemic circulation in the STEMI patients, but they may not be locally released from the IRA.