alexa Difficulty for Early Diagnosis of Alzheimer’s Disease: Especially MCI Level
ISSN: 2573-0312

Journal of Physiotherapy & Physical Rehabilitation
Open Access

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Short Communication

Difficulty for Early Diagnosis of Alzheimer’s Disease: Especially MCI Level

Koji Hori*, Chiaki Hashimoto, Ouga Sasaki, Masanori Tadokoro, Sachiko Tsukahara and Michiho Sodenaga

Department of Neuropsychiatry, St. Marianna University School of Medicine, Kawasaki, Japan

Corresponding Author:
Koji Hori
Department of Neuropsychiatry
St. Marianna University School of Medicine
Kawasaki, Japan
Tel: +81-44-977-8111
Fax: +81-44-976-3341
E-mail: [email protected]

Received Date: June 23, 2017; Accepted Date: June 27, 2017; Published Date: June 30, 2017

Citation: Hori K, Hashimoto C, Sasaki O, Tadokoro M, Tsukahara S, et al. (2017) Difficulty for Early Diagnosis of Alzheimer’s Disease: Especially MCI Level. Physiother Rehabil 2:146. doi:10.4172/2573-0312.1000146

Copyright: © 2017 Hori K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Early diagnosis of Alzheimer’s disease (AD) is very difficult. The main characteristic of neuro-image in AD is the atrophy of hippocampus and the main symptoms of AD is memory disturbance. However, we speculate these two sticks cause overdiagnosis or underdiagnoses of AD because the atrophy of hippocampus is not specific to AD and memory disturbance is not the first symptom in AD. As for memory disturbance, this symptom is not only unspecific to AD but also not the first symptom in AD. Moreover, we speculate that there two situations when the pathological symptoms occur at MCI in AD.On situation is when patients with AD at the MCI stage relax, at which time these patients show apathy. The other situation is when they are more stressed than usual. In this situation, these patients will be upset or panic. Therefore, the most important is hearing family of caregiver whether the patient shows apathy when he or she is relax (e.g., when they watch television, they fall asleep) and whether he or she is confused or panic when he or she is more stressed than usual.


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