alexa Diketopiperazines Produced by an Bacillus Species Inhibits Vibrio Parahaemolyticus | OMICS International | Abstract
ISSN: 2155-9546

Journal of Aquaculture Research & Development
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Research Article

Diketopiperazines Produced by an Bacillus Species Inhibits Vibrio Parahaemolyticus

Yanett Leyton1,2*, Jorge Borquez3, José Darias4, Mercedes Cueto4, Díaz-Marrero AR4 and Carlos Riquelme1

1Bioinnovation Center, Microbial Ecology Laboratory, Faculty of Marine Resources, Antofagasta University, Antofagasta, Chile

2Doctorate Applied Science, Mention Coastal Marine Systems, Faculty of Marine Resources, Antofagasta University, Antofagasta, Chile

3Laboratory of Natural Products, Department of Chemistry, Antofagasta University, Antofagasta, Chile

4Institute of Natural Products and Agrobiology. CSIC, La Laguna, Tenerife, Spain

*Corresponding Author:
Dr.Yanett Leyton
Bioinnovation Center, Microbial Ecology Laboratory
Faculty of Marine Resources
Universidad de Antofagasta, Antofagasta. Chile
Tel: +56-55-637532
Fax: +56-55-637804
E-mail: [email protected]

Received Date: June 20, 2012; Accepted Date: August 01, 2012; Published Date: August 10, 2012

Citation: Leyton Y, Borquez J, Darias J, Cueto M, Díaz-Marrero AR, et al. (2012) Diketopiperazines Produced by an Bacillus Species Inhibits Vibrio parahaemolyticus. J Aquacult Res Dev 3:144. doi:10.4172/2155-9546.1000144

Copyright: © 2012 Sarkar A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


In this work organic products were isolated and identified from a marine Bacillus sp. which presented growth inhibition of the pandemic strain of V.


. The inhibitory products were extracted and characterized by spectroscopic and


techniques. Purification of the active products revealed five different diketopiperazines, which were compared with standards from high-performance liquid chromatography (HPLC). Although the diketopiperazines is not a finding of a new metabolite, the interested point or novelity of this work is the ability of diketopiperazines to inhibit the growth of pandemic strain of V. parahaemolyticus. We suggest the possibility of using this compound to reduce the growth and control the proliferation of pathogenic clones of V.parahaemolyticus that cause several problems in aquaculture industry.


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