alexa Direct Determination of Four ACE-Inhibitors Lisinopril,
ISSN: 2157-7064

Journal of Chromatography & Separation Techniques
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Research Article

Direct Determination of Four ACE-Inhibitors Lisinopril, Enalapril, Captopril and Fosinopril in Pharmaceuticals and Serum by HPLC

Sultana N1, Naveed S1,2* and Arayne MS3
1Research Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Faculty of Pharmacy University of Karachi, Karachi-75270, Pakistan
2Jinnah University for Women, Karachi, Pakistan
3Department of Chemistry, University of Karachi, Pakistan
Corresponding Author : Safila Naveed
Research Institute of Pharmaceutical Sciences
Department of Pharmaceutical Chemistry
Faculty of Pharmacy, University of Karachi
Karachi-75270, Pakistan
E-mail: [email protected]
Received April 02, 2013; Accepted April 27, 2013; Published April 30, 2013
Citation: Sultana N, Naveed S, Arayne MS (2013) Direct Determination of Four ACE-Inhibitors Lisinopril, Enalapril, Captopril and Fosinopril in Pharmaceuticals and Serum by HPLC. J Chromat Separation Techniq 4:179. doi:10.4172/2157-7064.1000179
Copyright: © 2013 Sultana N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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The high performance liquid chromatography (HPLC)-UV method for the simultaneous determination of lisinopril, enalapril, captopril and fosinopril in human plasma is proposed. Good separation of the analytes was achieved by gradient RP-HPLC with the mobile phase composed as acetonitrile: water (60:40 v/v) adjusted to pH 3.0 by orthophosphoric acid. Lisinopril, enalapril, captopril and fosinopril were eluted from a Purospher STAR RP-and Hypersil ODS column in 1.8, 2.9, 3.2 and 5.4 min respectively. Good linear relationships were observed for all of the analytes (R2 higher than 0.995). Intra and inter-day precision and accuracy results were 98.0 to 102%. Application of the suggested procedure was successfully applied to the determination of theses compounds in active pharmaceutical preparations, dosage formulations and human serum with high percentage of recovery, good accuracy and precision (no interference of excepients) and this method can be applied to routine clinical analysis


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