Directional Activation of Intestinal Dendritic Cells by an Oral Targeted Multivalent Vaccine
Bikash Sahay, Jennifer L Owen and Mansour Mohamadzadeh*
Department of Infectious Diseases and Pathology, Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, and Emerging Pathogens Institute, University of Florida, Gainesville, FL 32601, USA
- *Corresponding Author:
- Mansour Mohamadzadeh
Director of the Center for Inflammation & Mucosal Immunology
Department of Infectious Diseases & Pathology
Division of Gastroenterology, Hepatology& Nutrition, Department of Medicine
University of Florida 2015 SW16th Ave, Building 1017
Room: V3-149, Gainesville, FL 32608, USA
E-mail: [email protected]
Received date: June 11, 2013; Accepted date: June 25, 2013; Published date: June 28, 2013
Citation: Sahay B, Owen JL Mohamadzadeh M (2013) Directional Activation of Intestinal Dendritic Cells by an Oral Targeted Multivalent Vaccine. J Vaccines Vaccin 4:192. doi: 10.4172/2157-7560.1000192
Copyright: © 2013 Sahay B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Parenteral injectionis the most common routeof administration for vaccines and therapeutics. Despite their frequent use, needle-based immunizations have several limitations; (i) needle phobias that are common in both adults and children, (ii) the requirement of trained medical personnel to administer vaccines, creating a limitation for mass vaccination, and (iii) accidental needle sticks, a serious concern in both developed and developing countries. Possible alternatives to injections have recently emerged and include (i) dermal and (ii) oral administration of vaccines. Here, we describe a methodology developed in our laboratory using intestinal bacteria that are considered safe for human consumption. Additionally, we have designed a dendritic cell (DC)-targeting sequence that delivers antigens directly to DCs. In this report, we discuss how DC-targeting peptide binding is not limited to human and murine antigen presenting cells; rather, it consistently binds with DCs of different species. Our data suggest that a DC-targeted oral vaccine platform could be used to develop vaccines for a variety of host animals.