alexa Discovering Novel Anti-Malarial Peptides from the Not-c
ISSN: 2332-0737

Current Synthetic and Systems Biology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Discovering Novel Anti-Malarial Peptides from the Not-coding Genome - A Working Hypothesis

Mukta Joshi1, Shankar V Kundapura1, Thirtha Poovaiah1, Kundan Ingle2 and Pawan K Dhar3*

1Symbiosis School of Biomedical Sciences, Symbiosis International University, Pune, India

2VLife Sciences Technologies Pvt. Ltd., Pune, India

3Centre for Systems and Synthetic Biology, University of Kerala, Kerala, India

*Corresponding Author:
Pawan K Dhar
Director, Centre for Systems and Synthetic Biology
University of Kerala, Trivandrum
Kerala, India 695 581
E-mail: [email protected]

Received date: June 18, 2013; Accepted date: August 17, 2013; Published date: August 21, 2013

Citation: Joshi M, Shankar VK, Poovaiah T, Ingle K, Dhar PK (2013) Discovering Novel Anti-Malarial Peptides from the Not-coding Genome - A Working Hypothesis. Curr Synthetic Sys Biol 1:103. doi:10.4172/2332-0737.1000103

Copyright: © 2013 Joshi M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The not-coding regions of the genome describe sequences that do not have a history of transcription. They are also called ‘dark matter’ of the genome. Here we present a working hypothesis for finding novel anti-malarial peptides from such regions of the yeast genome that encode neither RNA nor protein. This is based on our previous experimental work where not-coding DNA sequences were artificially expressed leading to protein expression and phenotypic outcome. In this study, we explored the vast not-coding DNA space of Saccharomyces cerevisiae in search of novel antimalarial peptides. Given the lack of effective therapeutic solutions against malaria, there is an urgent unmet requirement to find novel antimalarial drugs and targets. Our initial efforts to find novel anti-malarial peptides have led to unexpected and interesting results. However, our work is preliminary and is based on computational studies only. In future, more computational and experimental work is needed to establish therapeutic potential of synthetic peptides that have origins in the not-coding genome space.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version