Discovering Novel Anti-Malarial Peptides from the Not-coding Genome - A Working Hypothesis
- *Corresponding Author:
- Pawan K Dhar
Director, Centre for Systems and Synthetic Biology
University of Kerala, Trivandrum
Kerala, India 695 581
E-mail: [email protected]
Received date: June 18, 2013; Accepted date: August 17, 2013; Published date: August 21, 2013
Citation: Joshi M, Shankar VK, Poovaiah T, Ingle K, Dhar PK (2013) Discovering Novel Anti-Malarial Peptides from the Not-coding Genome - A Working Hypothesis. Curr Synthetic Sys Biol 1:103. doi:10.4172/2332-0737.1000103
Copyright: © 2013 Joshi M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The not-coding regions of the genome describe sequences that do not have a history of transcription. They are also called ‘dark matter’ of the genome. Here we present a working hypothesis for finding novel anti-malarial peptides from such regions of the yeast genome that encode neither RNA nor protein. This is based on our previous experimental work where not-coding DNA sequences were artificially expressed leading to protein expression and phenotypic outcome. In this study, we explored the vast not-coding DNA space of Saccharomyces cerevisiae in search of novel antimalarial peptides. Given the lack of effective therapeutic solutions against malaria, there is an urgent unmet requirement to find novel antimalarial drugs and targets. Our initial efforts to find novel anti-malarial peptides have led to unexpected and interesting results. However, our work is preliminary and is based on computational studies only. In future, more computational and experimental work is needed to establish therapeutic potential of synthetic peptides that have origins in the not-coding genome space.