alexa Discrepancies of 11C-MET Uptake and MRI Contrast Enhancement in a Glioblastoma: A PET/MRI Case Report
ISSN: 2157-7099

Journal of Cytology & Histology
Open Access

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Case Report

Discrepancies of 11C-MET Uptake and MRI Contrast Enhancement in a Glioblastoma: A PET/MRI Case Report

Tian J1*, Fu L1, Yuan J2, Liu J1, Chen X2, Shi H2 and Xu B1
1Department of Nuclear Medicine, The Chinese PLA General Hospital, Fuxing Rd. 28, Beijing, 100853, China
2Department of Pathology, The Chinese PLA General Hospital, Fuxing Rd. 28, Beijing, 100853, China
*Corresponding Author : Tian J
Department of Nuclear Medicine
The Chinese PLA General Hospital
Fuxing Rd. 28, Beijing, 100853, PR China
Tel: +8610 66887329
Received: December 05, 2015; Accepted: February 01, 2016; Published: February 03, 2016
Citation: Tian J, Fu L, Yuan J, Liu J, Chen X, et al. (2016) Discrepancies of 11C-MET Uptake and MRI Contrast Enhancement in a Glioblastoma: A PET/MRI Case Report. J Cytol Histol S5:003. doi:10.4172/2157-7099.S5-003
Copyright: © 2016 Tian J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


A 58-year-old female patient suffered from convulsion in the left upper limb and weakness in the left lower extremity for one month. In MR contrast-enhancing (CE) images, obvious rim-enhancement was only found in the frontal nodule, while fused 11C-MET PET/MRI images showed increased MET uptake not only in the right frontal lesion but also in the body of corpus callosum. We postulated the discrepancy between MRI CE and MET uptake for the corpus callosum lesion maybe due to the following two reasons: firstly, a relative low malignant potential where absent of BBB disruption; secondly, the special affinity of MET to the oligodendroglioma. In addition, the 1H-MRS, TDI and ASL data acquired simultaneously with PET scan indicated the frontal lesion had the features of typical malignant intracranial tumor. Finally, the pathological results confirmed the frontal lesion a WHO-IV grade glioblastoma with partial anaplasia oligodendroglioma. The imaging follow-up showed a newly abnormal CE in the body of corpus callosum, which was consistent with the previous increased MET uptake on PET/MRI examination. Our case indicates that one-stop multiparametric MET-PET/MRI has advantages for the management of intracranial tumor lesions by providing complementary information.


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