Disease-Specific and Common HLA and Non-HLA Genetic Markers in Susceptibility to Rheumatoid Arthritis, Type 1 Diabetes Mellitus and Multiple Sclerosis
- Corresponding Author:
- Nikolajs Sjakste
Latvian Institute of Organic Synthesis
No. 21 Aizkraukles Street, Riga LV-1006, Latvia
E-mail: [email protected]
Received date: February 28, 2014 Accepted date: April 11, 2014 Published date: April 21, 2014
Citation: Sjakste T, Kalnina J, Paramonova N, Nikitina-Zake L, Sjakste N (2014) Disease-Specific and Common HLA and Non-HLA Genetic Markers in Susceptibility to Rheumatoid Arthritis, Type 1 Diabetes Mellitus and Multiple Sclerosis. J Mol Genet Med 8:119. doi: 10.4172/1747-0862.1000119
Copyright: © 2014 Sjakste T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Autoimmune diseases cause numerous health and social problems throughout the world. The common spectrum of autoimmune diseases affect the majority of tissues within the body, including pancreatic beta cells in type 1 diabetes (T1DM), myelin surrounding nerve axons in Multiple sclerosis (MS) and synovial joint antigens in Rheumatoid Arthritis (RA). The diseases are likely caused by a complex interaction between multiple HLA- and non- HLA related genes and environmental factors. The well documented co-clustering of autoimmune diseases within families and individuals, together with apparent sharing of number risk genes between the diseases suggests at least some common mechanisms of autoimmune development.