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ISSN: 2161-105X

Journal of Pulmonary & Respiratory Medicine
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Research Article

Disparate Species-Dependent Leukocyte Behavior before and after Adding an Elastase Inhibitor

Nicholas J Cheronis1#, Nathan A Groathouse2#, Richard A Bowen2, Sanford R Simon3, John C Cheronis1 and John E Repine4*

1Paradocs Biomedical, Ltd., Breckenridge, CO, USA

2Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA

3Department of Pathology and Biochemistry, State University of New York, Stony Brook, NY, USA

4Webb-Waring Center and University of Colorado Denver Health Sciences Center, Aurora, CO, USA

#These authors contributed equally to this work

*Corresponding Author:
John E Repine, M.D
Webb-Waring Center. 12850
East Montview Blvd., Aurora
CO 80045, USA
Tel: 303-724-4788
E-mail: [email protected]

Received date: July 29, 2013; Accepted date: August 28, 2013; Published date: August 30, 2013

Citation: Cheronis NJ, Groathouse NA, Bowen RA, Simon SR, Cheronis JC, et al. (2013) Disparate Species-Dependent Leukocyte Behavior before and after Adding an Elastase Inhibitor. J Pulm Respir Med 3:155 doi: 10.4172/2161-105X.1000155

Copyright: © 2013 Cheronis NJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Animal models are often used to identify aspects of the pathophysiology and to develop new therapeutic interventions for human disorders. Leukocyte serine elastases are key mediators of inflammation and meaningful therapeutic targets because of their potential contributions to the Acute Respiratory Distress Syndrome (ARDS) and other inflammatory disorders. We compared the extracellular matrix degrading and bactericidal activities against both Escherichia coli and Staphylococcus aureus, of leukocytes from humans, dogs, hamsters, rats, pigs and rabbits before and after adding highly selective serine elastase inhibitors. Not surprisingly, we found significant species-dependent differences in both activities and the responses to adding serine elastase inhibitors. Our results reinforce the need for care in selecting the optimal animal species for evaluating both the underlying pathophysiology of inflammatory diseases and potential new interventions being developed to treat these conditions.

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