Disposable No Longer: The Spleen Holds a Reservoir of Stem CellsDenise L Faustman1,2*, Claudia Giesecke5, Miriam Davis2, Willem M Kühtreiber1,2, Simon D Tran3, Thomas Dörner5 and Eric J Ley4
- *Corresponding Author:
- Denise L Faustman
Director, Immunobiology Laboratory
Associate Professor of Medicine
Harvard Medical School, USA
E-mail: [email protected]
Received date: June 30, 2014; Accepted date: July 25, 2014; Published date: July 27, 2014
Citation: Faustman DL, Giesecke C, Davis M, Kühtreiber WM, Tran SD, et al. (2014) Disposable No Longer: The Spleen Holds a Reservoir of Stem Cells. J Stem Cell Res Ther 4:219. doi: 10.4172/2157-7633.1000219
Copyright: © 2014 Faustman DL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Regenerative medicine is coming to recognize the value of a stem cell population that is unique to the spleen. This splenic stem cell population can robustly facilitate adult end organ regeneration and it expresses a key embryonic transcription factor, Hox11, which regulates organogenesis in diverse vertebrate species. This review article discusses the identification of this Hox11 stem cell population for its therapeutic potential in the pancreas, salivary glands, heart, bone and cranial neurons for organ regeneration. It also discusses the deleterious effects of Hox11 stem cells in cancer, in which malignant cells revert to a Hox11 phenotype, and in certain forms of autoimmunity, in which Hox11 lineages of cells may contribute to abnormal development of end organs.