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Disposable No Longer: The Spleen Holds a Reservoir of Stem Cells | OMICS International | Abstract
ISSN: 2157-7633

Journal of Stem Cell Research & Therapy
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Review Article

Disposable No Longer: The Spleen Holds a Reservoir of Stem Cells

Denise L Faustman1,2*, Claudia Giesecke5, Miriam Davis2, Willem M Kühtreiber1,2, Simon D Tran3, Thomas Dörner5 and Eric J Ley4

1Harvard Medical School, Boston MA, USA

2Immunobiology Laboratory, Massachusetts General Hospital, Boston MA, USA

3Faculty of Dentistry, McGill University, Montreal, Canada

4Department of Surgery, Cedars-Sinai Medical Center, Los Angeles CA, USA

5Department of Medicine and Rheumatology, Charity Hospital, Berlin, Germany

*Corresponding Author:
Denise L Faustman
Director, Immunobiology Laboratory
Associate Professor of Medicine
Harvard Medical School, USA
Tel: 617-726-4084
Fax: 617-726-4095
E-mail: [email protected]

Received date: June 30, 2014; Accepted date: July 25, 2014; Published date: July 27, 2014

Citation: Faustman DL, Giesecke C, Davis M, Kühtreiber WM, Tran SD, et al. (2014) Disposable No Longer: The Spleen Holds a Reservoir of Stem Cells. J Stem Cell Res Ther 4:219. doi: 10.4172/2157-7633.1000219

Copyright: © 2014 Faustman DL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Regenerative medicine is coming to recognize the value of a stem cell population that is unique to the spleen. This splenic stem cell population can robustly facilitate adult end organ regeneration and it expresses a key embryonic transcription factor, Hox11, which regulates organogenesis in diverse vertebrate species. This review article discusses the identification of this Hox11 stem cell population for its therapeutic potential in the pancreas, salivary glands, heart, bone and cranial neurons for organ regeneration. It also discusses the deleterious effects of Hox11 stem cells in cancer, in which malignant cells revert to a Hox11 phenotype, and in certain forms of autoimmunity, in which Hox11 lineages of cells may contribute to abnormal development of end organs.


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