alexa Dissecting the Roles of Natural Killer T cells in Autoimmune Disorders and Malignancy
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

Dissecting the Roles of Natural Killer T cells in Autoimmune Disorders and Malignancy

Bimonte Sabrina1*, Barbieri Antonio1, Palma Giuseppe1,2, Turco Maria Caterina3 and Arra Claudio1
1Struttura Semplice Dipartimentale Sperimentazione Animale, Istituto Nazionale dei Tumori, IRCCS “Fondazione G. Pascale”, Via Mariano Semmola, 80131, Naples, Italy
2Istituto di Endocrinologia e Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare “L. Califano”, Università degli Studi di Napoli “Federico II”, Via Pansini 5, 80131 Napoli, Italy
3University of Salerno, Fisciano (SA), Italy
Corresponding Author : Bimonte Sabrina
Struttura Semplice Dipartimentale Sperimentazione Animale
Istituto Nazionale dei Tumori
IRCCS Fondazione G. Pascale
Via Mariano Semmola, 80131, Naples, Italy
E-mail: [email protected] istitutotumori.na.it
Received September 21, 2012; Accepted November 02, 2012; Published November 09, 2012
Citation: Sabrina B, Antonio B, Giuseppe P, Caterina TM, Claudio A (2012) Dissecting the Roles of Natural Killer T cells in Autoimmune Disorders and Malignancy. J Clin Cell Immunol S10:005. doi:10.4172/2155-9899.S10-005
Copyright: © 2012 Sabrina B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Natural killer T (NKT) cells are a heterogeneous group of T cells that share properties of both T cells and natural killer (NK) cells. Many of these cells recognize the non-polymorphic CD1d molecule, an antigen-presenting molecule that binds self and non-self glycolipids and lipids. NKT cells are able to influence autoimmune and cancer diseases, thanks to their innate and adaptative immune properties. A hallmark of NKT cells is their ability to express proand anti-inflammatory T helper(h)1 and Th2 cytokines upon antigenic stimulation, and to modify both inflammatory mediators and late stage T cell responses. Thus, NKT cells are considered critical cells in regulatory events that direct the inflammatory response. Additionally, NKT cells can regulate the functions of other NKT subsets. The purpose of this review is to highlight the importance of NKT cells as regulators of autoimmunity disorders and cancer.

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