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Disseminated Histoplasmosis Seasonal Incidence Variations: A Supplementary Argument for Recent Infection? | OMICS International | Abstract
ISSN 2155-6113

Journal of AIDS & Clinical Research
Open Access

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Short Communication

Disseminated Histoplasmosis Seasonal Incidence Variations: A Supplementary Argument for Recent Infection?

Matthieu Hanf1*, Antoine Adenis1, Bernard Carme1,3, Pierre Couppie2,3 and Mathieu Nacher1,3,4

1Centre d’Investigation Clinique Epidémiologie Clinique Antilles Guyane CIC-EC INSERM CIE 802, Cayenne General Hospital, Cayenne, French Guiana

2Department of Dermatology, Cayenne General Hospital, Cayenne, French Guiana

3Department of Parasitology and Mycology – Team EA 3593, Université des Antilles et de la Guyane, Cayenne General Hospital, Cayenne, French Guiana

4COREVIH, Cayenne General Hospital, Cayenne, French Guiana

*Corresponding Author:
Matthieu Hanf
Centre d’Investigation Clinique Epidémiologie Clinique Antilles Guyane CIC-EC CIE 802
Cayenne General Hospital, EHPAD, Avenue des Flamboyants
BP 6006 97300 Cayenne, French Guiana, France
E-mail: [email protected]

Received Date: August 30, 2012; Accepted Date: October 10, 2012; Published Date: October 15, 2012

Citation: Hanf M, Adenis A, Carme B, Couppie P, Nacher M (2012) Disseminated Histoplasmosis Seasonal Incidence Variations: A Supplementary Argument for Recent Infection? J AIDS Clinic Res 3:175. doi:10.4172/2155-6113.1000175

Copyright: © 2012 Hanf M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: In French Guiana, a recent study has shown that a major part of the histoplasmosis incidence temporal fluctuations could be explained by climatic factors and thus postulated that disseminated histoplasmosis cases could be in a large proportion due to new infections. The description of the seasonal pattern of histoplasmosis could potentially help to test this new hypothesis. Patients and methods: A study using prospective data from the French Hospital Database for HIV was conducted in order to determine seasonal variations of the incidence of first cases of disseminated histoplasmosis in HIV persons in Cayenne, French Guiana. Single failure Cox proportional hazards models were used. Results: After adjusting for CD4 counts and antiretroviral treatment, the incidence of disseminated histoplasmosis was significantly higher during the Short Wet Season–Long Dry Season than during the Short Dry Season–Long Wet Season (Adjusted Hazard ratio 1.7 (1.1-2.5), P= 0.01). Conclusion: This result gives both valuable epidemiologic information to clinicians and a supplementary argument in favour of the hypothesis that an important proportion of cases were due to recent exposure. Therefore, the use of a primary prophylaxis must be discussed in French Guiana.

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