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Diurnal Spatial Rearrangement of Microglial Processes through the Rhythmic Expression of P2Y12 Receptors | OMICS International | Abstract
ISSN: 2329-6895

Journal of Neurological Disorders
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Research Article

Diurnal Spatial Rearrangement of Microglial Processes through the Rhythmic Expression of P2Y12 Receptors

Yoshinori Hayashi1, Satoru Koyanagi2, Naoki Kusunose2, Fumiko Takayama1, Ryo Okada1, Zhou Wu1, Shigehiro Ohdo2 and Hiroshi Nakanishi1,3*
1Faculty of Dental Sciences, Department of Aging Science and Pharmacology, Kyushu University, Fukuoka, Japan
2Faculty of Pharmaceutical Sciences, Pharmaceutics, Kyushu University, Fukuoka, Japan
3Japan Science and Technology Agency, CREST, 5, Sanbancho, Chiyoda-ku, Tokyo, Japan
Corresponding Author : Dr. Hiroshi Nakanishi
Faculty of Dental Sciences
Department of Aging Science and Pharmacology
Kyushu University, Fukuoka, 812-8582, Japan
Fax: +81 92 642 6415
E-mail: [email protected]
Received May 20, 2013; Accepted June 19, 2013; Published June 21, 2013
Citation: Hayashi Y, Koyanagi S, Kusunose N, Takayama F, Okada R, et al. (2013) Diurnal Spatial Rearrangement of Microglial Processes through the Rhythmic Expression of P2Y12 Receptors. J Neurol Disord 1:120. doi: 10.4172/2329-6895.1000120
Copyright: © 2013 Hayashi Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Microglia plays important roles in synaptic reorganization during the postnatal developmental stage. Moreover, microglia continuously surveys the functional state of the synapse and change to improve the function. This phenomenon was attributed to the fine process of extension and retraction. However, the mechanism underlying the dynamics of microglial movement and function is still unclear. We herein report that cortical microglia exhibit clock gene-regulated diurnal morphological changes. Cortical microglia extended their processes during the dark phase and retracted them during the light phase. These diurnal changes were also observed in cortical microglia from animals housed under constant darkness, but not in cortical microglia from clock-mutant mice. The mean contact ratio of the microglia-synapse interactions was significantly larger during the dark phase than the light phase. These diurnal changes in microglial morphology and microglia-synaptic interactions were significantly inhibited by the systemic administration of clopidogrel, a P2Y12 receptor (P2Y12R) blocker. We further observed diurnal variation in the P2Y12R expression in cortical microglia. The reporter analyses further revealed that P2Y12R was regulated by a negative feedback loop of the clock system. These observations suggest that the microglial clock system drives the diurnal morphological changes of microglia and microglia-synapse interactions by controlling the P2Y12R expression.


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