alexa DNA Methylation in Cancer Tissues
ISSN: 2157-7013

Journal of Cell Science & Therapy
Open Access

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Review Article

DNA Methylation in Cancer Tissues

Daud Faran Asif*, Naveed M and Umer Rashid

Department of Biochemistry and Biotechnology, University of Gujrat, Gujrat, Pakistan

*Corresponding Author:
Daud Faran Asif
Department of Biochemistry and Biotechnology
University of Gujrat, Gujrat, Pakistan
Tel: 92533643112
E-mail: [email protected]

Received Date: May 21, 2017; Accepted Date: May 27, 2017; Published Date: May 29, 2017

Citation: Asif DF, Naveed M, Rashid U (2017) DNA Methylation in Cancer Tissues. J Cell Sci Ther 8:272. doi: 10.4172/2157-7013. 1000272

Copyright: © 2017 Asif DF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

 

Abstract

Cancer linked DNA hypo-methylation and hyper-methylation are present throughout the human genome. The hyper-methylation facilitates cancer progress by repressing the tumor suppressor gene. Hypo-methylation contribution towards cancer has not yet been clear. Recent studies of tissue specific methylation have suggested that DNA hypo-methylation aid tumor formation by many pathways. Loss of DNA methylation associated with cancer may alter transcription. In addition, DNA hypo-methylation might affect promoter usage production of intra-genic non-coding RNA transcripts, co-transcriptional splicing and initiation and elongation of transcription. Studies of hemi methylation of DNA in cancerous cells as well as normal tissues suggest that active de-methylation can explain cancer associated DNA hypo-methylation. New studies that genomic 5-hydroxymethylcytosine is intermediate in DNA de-methylation exhibits cancer associated losses. It suggests that both decreased hydroxyl-methylation and methylation of DNA play important role in carcinogenesis.

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