alexa DNA Methylation in Chronic Myeloid Leukemia | OMICS International | Abstract
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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Review Article

DNA Methylation in Chronic Myeloid Leukemia

Elisa Leo* and Giovanni Martinelli

Istituto di Ematologia “L. e A. Seràgnoli”, DIMES, Università di Bologna, via Massarenti 9, Bologna, Italy

Corresponding Author:
Elisa Leo, PhD
Istituto di Ematologia “L. e A. Seràgnoli” – DIMES – Università di Bologna
via Massarenti 9, 40138 Bologna – Italy
Tel: +390516363791
Fax: +390516364037
E-mail: [email protected]

Received date: June 10, 2014; Accepted date: July 10, 2014; Published date: July 20, 2014

Citation: Leo E and Martinelli G (2014) DNA Methylation in Chronic Myeloid Leukemia. J Mol Genet Med 08:118. doi: 10.4172/1747-0862.1000118

Copyright: © 2014 Leo E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

Abstract

Despite the high efficiency of tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia, 20-25% of patients develop drug resistance resulting in therapy failure. Besides mutations of the BCR-ABL1 kinase domain, the abnormal epigenetic regulation of the expression of critical genes for cell proliferation and survival has a central role in the disease pathogenesis and progression towards the drug resistant phenotype. Such epigenetic changes have the potential to be modulated by specific drugs including demethylating agents and histone deacetylase inhibitors. Here the current knowledge on the BCR-ABL1-associated methylation status is reviewed.

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