Journal of Molecular and Genetic Medicine
Open Access

DNMT1 and Genomic Instability in Cancer

Viviana Barra^*

Dipartimento Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Palermo, Italy

Corresponding Author:

Viviana Barra
Dipartimento Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF)
University of Palermo, Palermo, Italy
Tel: 904-244-9361
Fax: 904-244-9361
E-mail: sbalaiyaufl.edu

Received date: March 10, 2014; Accepted date: April 25, 2014; Published date: June 28, 2014

Citation: Barra V (2014) DNMT1 and Genomic Instability in Cancer. J Mol Genet Med 8:113. doi: 10.4172/1747-0862.1000113

Copyright: © 2014 Barra V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

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DNA (cytosine 5-) MethylTransferase 1 (DNMT1) maintains the pre-existing methyl marks onto daughter strands by faithfully copying the methylation pattern from hemimethylated DNA during replication phase. The fundamental role of DNA methylation in cell physiology makes a controlled regulation of DNMT1 necessary. DNMT1 loss and global DNA hypomethylation are correlated with genomic instability in cancer. This mini review aims to provide a scenario of the mechanisms whereby DNMT1 dysfunction could induce https://www.omicsonline.org/open-access/genomics-of-colorectal-cancer-in-african-americans-2469-9853-1000133.php?aid=80577 instability so as to clarify its functions and understand the dynamics of DNA methylation at cellular level with a focus on cancer.