Review Article
DNMT1 and Genomic Instability in Cancer
Viviana Barra*
Dipartimento Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Palermo, Italy
- Corresponding Author:
- Viviana Barra
Dipartimento Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF)
University of Palermo, Palermo, Italy
Tel: 904-244-9361
Fax: 904-244-9361
E-mail: sbalaiyaufl.edu
Received date: March 10, 2014; Accepted date: April 25, 2014; Published date: June 28, 2014
Citation: Barra V (2014) DNMT1 and Genomic Instability in Cancer. J Mol Genet Med 8:113. doi: 10.4172/1747-0862.1000113
Copyright: © 2014 Barra V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
Abstract
DNA (cytosine 5-) MethylTransferase 1 (DNMT1) maintains the pre-existing methyl marks onto daughter strands by faithfully copying the methylation pattern from hemimethylated DNA during replication phase. The fundamental role of DNA methylation in cell physiology makes a controlled regulation of DNMT1 necessary. DNMT1 loss and global DNA hypomethylation are correlated with genomic instability in cancer. This mini review aims to provide a scenario of the mechanisms whereby DNMT1 dysfunction could induce https://www.omicsonline.org/open-access/genomics-of-colorectal-cancer-in-african-americans-2469-9853-1000133.php?aid=80577 instability so as to clarify its functions and understand the dynamics of DNA methylation at cellular level with a focus on cancer.
