Do Moonlighting Proteins Belong to the Intrinsically Disordered Protein Class?
- *Corresponding Author:
- Dr. Enrique Querol
Institute of Biotechnology and Biomedicine
Department of Biochemistry and Molecular Biology
Universitat Autònoma de Barcelona
08193 Bellaterra, Barcelona, Spain
E-mail: [email protected]
Received Date: October 05, 2012; Accepted Date: November 08, 2012; Published Date: November 15, 2012
Citation: Hernández S, Amela I, Cedano J, Piñol J, Perez-Pons JA, et al. (2012) Do Moonlighting Proteins Belong to the Intrinsically Disordered Protein Class? J Proteomics Bioinform 5: 262-264. doi: 10.4172/jpb.1000247
Copyright: © 2012 Hernández S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Moonlighting is the capability of some proteins to execute two or more biological functions. According to some authors, there is a relationship between protein conformational fluctuations and promiscuous functions of proteins. This promiscuity would be due to the conformational properties of the structurally disordered regions. To check if moonlighting proteins belong to the Intrinsically Disordered Protein (IDP) class, we have predicted IDP/IDR (Intrinsically Disordered Regions) for a number of moonlighting proteins. Our results suggest that most moonlighting proteins do not belong to the IDP class.