alexa Do the Adult Daughters of PCOS Patients Develop PCOS and Is This Due to an Androgenized Uterine Environment-An Online Epidemiological Survey | OMICS International | Abstract
ISSN: 2161-038X

Reproductive System & Sexual Disorders: Current Research
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Research Article

Do the Adult Daughters of PCOS Patients Develop PCOS and Is This Due to an Androgenized Uterine Environment-An Online Epidemiological Survey

Agnieszka Ratajczak1, Ray Kruse Iles2*# and Xuesong Wen1*#

1Department of Natural Sciences, Middlesex University, The Burroughs, Hendon, London, UK

2MAP Diagnostics, The BioPark, Welwyn Garden City, UK

#Both authors have contributed equally.

*Corresponding Author's:
Iles RK
MAP Diagnostics, The BioPark
Welwyn Garden City
Tel: +44 (0)1353361364
E-mail: [email protected]

Wen X
Department of Natural Sciences
Middlesex University
The Burroughs, Hendon
London NW4 4BT, UK
Tel: +44 (0)208 411 493
E-mail: [email protected]

Received date: April 6, 2016; Accepted date: April 18, 2016; Published date: April 25, 2016

Citation: Ratajczak A, Iles RK, Wen X (2016) Do the Adult Daughters of PCOS Patients Develop PCOS and Is This Due to an Androgenized Uterine Environment-An Online Epidemiological Survey. Reprod Syst Sex Disord 5:167. doi:10.4172/2161-038X.1000167

Copyright: © 2016 Ratajczak A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objectives: Several inconsistent studies have investigated whether the uterine environment of androgenized pregnant women is a risk factor for an in-utero developmental imprinted predisposition towards subsequent polycystic ovarian syndrome (PCOS) among their female offspring. These are difficult to compare due to variable parameters and subject selection criteria. Few epidemiological studies have analyzed the incidence of PCOS amongst adult daughters of PCOS affected women previously. Our study aimed to investigate risk factors relating to the development of PCOS in the female offspring of PCOS patients.

Methods: We used a questionnaire to collect a mother-to-daughter medical history and relevant information, in order to understand risk factors, which might relate to the presence of PCOS daughters of PCOS patients.

Results: Of four hundred and one responses, 131 participants were included in the final analysis. There was no statistical association with the subsequent development of PCOS amongst female offspring of women with PCOS. However, there was a significantly higher prevalence of post-term birth among PCOS mothers. Nevertheless, the major determinant of risk of subsequent incidence of PCOS amongst daughters was a higher BMI, regardless of the mothers BMI.

Conclusion: Socio-economic family influences, affecting BMI, may be the reason for any mother to daughter association with PCOS.


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