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ISSN: 2165-7890

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Review Article

Do the Stem Cells Really Work with Autism Spectrum Disorders Associated with Neuro-Immune Interaction?

Gao Shane1*, Xu Jun1, Wang Juan2, Wu Zeyang1,Yuan Ping3, Gao Fengjuan4, Cao Limei4, Chen Xu4, Zhou fei5 and Zhu Hongwen6

1East Hospital, Tongji University School of Medicine, Shanghai 200120, China

2Department of Biotechnology, Binzhou Medical College, Yantai, Shandong Province, 264003, China

3Tongji Hospital affiliated to Tongji University, Shanghai 200092, China

4Shanghai Eighth People’s Hospital Affiliated to Jiangsu University, Shanghai 200233, China

5Shanghai ChangZheng Hospital Affiliated to the Second Military Medical School, Shanghai, 200003, China

6Tianjin Hospital, Tianjin 300211, China

*Corresponding Author:
Shane G
East Hospital, Tongji University School of Medicine
Shanghai 200120, China
Tel: 86-15801709849
E-mail: [email protected]

Received: August 13, 2015; Accepted: September 26, 2015; Published: October 03, 2015

Citation: Shane G, Jun X, Juan W, Zeyang W, Ping Y, et al. (2015) Do the Stem Cells Really Work with Autism Spectrum Disorders Associated with Neuro-Immune Interaction?. Autism Open Access 5:151. doi:10.4172/2165-7890.1000151

Copyright: © 2015 Shane G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Abstract

Autism spectrum disorders (ASDs), namely neurodevelopmental disorders encompassing impairments in communication, social interactions and restricted stereotypical behaviors, induces a relatively high morbidity and mortality ratio (1/166) in modern children's life. One of the serious factors accounting for ASDs is the failure of the appropriate neuro-immune interaction. Although a relationship between altered immune responses and ASDs was firstly recognized nearly 40 years ago, only recently has new evidence started to shed light on the complex multifaceted communication between neuro-immune dysfunction and behavior in ASDs. Extensive alterations in immune function have now been described in both children and adults with ASDs, including ongoing inflammation in brain specimens, elevated pro-inflammatory cytokine profiles in the Cerebro-Spinal Fluid (CSF) and blood, increased presence of brain-specific auto-antibodies and altered immune cell function. Accumulated data both from clinical and lab research proposed the essential role of neuro-immune interaction during the pathogenesis of ASDs. Stem cells, which account for normal turnover and injury repair, might do great favors on ASDs due to their ability to give rise to new functional cells as a cell replacement source, paracrine secretion as trophic and cytokine contributor, immune modulator to balance the pro-inflammation and anti-inflammation as well as the inhibitor of chronic inflammation in ASDs brain, etc. Here in this review, we focus on the current development of stem cell administration in ASDs especially on mesenchymal stem cells (MSCs), which proved to be the most plastic and efficient to interfere with ASDs neuro-immune interaction, moreover summarize the propbable mechanism and efficient therapeutic methods to treat ASDs withMSCs.

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