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Hereditary Genetics: Current Research
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Research Article

Does Consanguinity Protect Against Breast Cancer in Tunisian Population?

Troudi Cherif W1-3*, Uhrhummer N4, Ben Ayed F2, Bignon YJ3, Sibille C5, Benammar-Elgaaied A1 and Ennafaa H1

1Laboratory of Genetics, Immunology and Human Pathology at the Faculty of Sciences of Tunis, Faculty of Sciences of Tunis, University El Manar I 1060 Tunis, Tunisia

2Central University 03, Rue Hammadi Eljaziri, 1002 Tunis, Tunisia

3Salah Azaiez Institute of Carcinology of Tunis, Boulevard 09 Avril – 1006 Bab Saadoun Tunisia

4Laboratoire de Diagnostic Genetique et Moleculaire, Centre Jean-Perrin. 63011 Clermont-Ferrand, Cedex 01 France

5Laboratory of Molecular Genetic of Hereditary Pathologies, Center of Human Genetics UCL, Avenue E.Mounier- Entree F. B 1200 Bruxelles

*Corresponding Author:
Wafa Troudi Cherif
Central University 03
Rue Hammadi Eljaziri
1002 Tunis. Tunisia
Tel: 0021671793379 (144)
Fax: 0021671793558
Email: [email protected]

Received date November 20, 2013; Accepted date: May 13, 2014; Published date: May 15, 2014

Citation: Cherif WT, Uhrhummer N, Ayed FB, Bignon YJ, Sibille C, et al. (2014) Does Consanguinity Protect Against Breast Cancer in Tunisian Population?. Hereditary Genet 3:130. doi: 10.4172/2161-1041.1000130

Copyright: © 2014 Cherif WT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Consanguinity is highly prevalent in many parts of the world. The highest consanguinity rates (20% to 50% of all marriages) occur in North Africa, the Middle East, Southwest Asia and Southern India. The aim of this study is to assess the effect of consanguineous marriages on the incidence of sporadic and familial breast cancer in Tunisia. We ascertained the rate of consanguineous marriage and the average coefficient of inbreeding among 155 Tunisian patients diagnosed with sporadic or familial breast cancer. The coefficient of inbreeding among all breast cancer patients was 0,007. No difference was observed for sporadic (F=0.008) vs familial breast cancer (F=0.007). The coefficient of inbreeding was significantly lower in the breast cancer group than in the Tunisian general population (0.0157). Considering the age of the patients, the level of inbreeding was lower among patients older than 50 (F=0.0027), while those younger than 50 exhibited a coefficient of inbreeding similar to that of the general population (F=0.01). The protective effect of consanguinity against breast cancer, particularly for patients older than 50 years, may be related to the absence of major factors involved in the onset of breast cancer at an early age. This protective effect may be also related to the contribution of recessive alleles of modifier or low-penetrance genes in the homozygous state.

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