Does Exist A Correlation Between BMI and Gleason Patterns 4 and 5 At Prostate Biopsy?Vincenzo Serretta1*, Giovanni Caruana1, Francesco Sommatino1, Salvatore Scurria1,Giuseppe Carità1, Luigi Vaccarella1, Federico Torretta2, Giuseppe Cicero3, Marcello Daricello4, Vito Franco5
- *Corresponding Author:
- Vincenzo Serretta
Department of Surgical
Oncological and Stomathological Sciences
University of Palermo, Italy
E-mail: [email protected]
Received date: July 09, 2013; Accepted date: August 30, 2013; Published date: September 02, 2013
Citation: Serretta V, Caruana G, Sommatino F, Scurria S, Carità G, et al. (2013) Does Exist A Correlation Between BMI and Gleason Patterns 4 and 5 At Prostate Biopsy? J Cytol Histol 4:182. doi:10.4172/2157-7099.1000182
Copyright: © 2013 Serretta V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Obesity has been related with higher Gleason grade and worse prognosis. Increasing proportion of Gleason pattern 4 or 5 is a critical factor for biochemical recurrence, progression and mortality. The endocrine activity of visceral fat could be responsible of the differentation of the prostatic malignant cell towards a more aggressive fenotype. The aim of our study was to correlate Body Mass Index with the presence of Gleason pattern 4 or higher at biopsy.
Materials and Methods: Consecutive patients with positive prostate biopsy were included. A transrectal prostate biopsy procedure with 12 cores, was performed. All tissue samples were reviewed.
Results: Out of 135 patients diagnosed with prostate cancer at biopsy, a Gleason. pattern 4 or 5 was evident in 57 (42%) patients, while it was not detected in 78 (58%). The statistical analysis did not demonstrate a correlation between the histological expression of Gleason pattern 4 or 5 in the bioptic specimens and the BMI class.
Conclusion: Although high risk prostate cancer has been reported more frequent in patients with higher BMI, in our experience, no significant correlation between BMI and Gleason patterns 4 and 5 at biopsy was detected. Other factors responsible for the worse prognosis and the more aggressive behavior of prostate tumors in obeses should be investigated.