Does Oral Lycopene Reduce Benign Prostate Enlargement/Hyperplasia (BPE/BPH)?
|Hitendra RH Patel1*, Walid Elbakbak2, Amina Bouhelal3 and Stig Müller4|
|1Department of Urology, University Hospital North Norway, Tromso, Norway|
|2Bart´s Cancer Insitute, Queen Mary University of London, UK|
|3Royal Free Hospital, University College of London, UK|
|4Department of Urology, Akershus University Hospital, Institute of Clinical Medicine, University of Oslo, Norway|
|*Corresponding Author :||Hitendra RH Patel
Department of Urology
University Hospital North Norway
Tel: +47 07766
E-mail: [email protected]
|Received: January 11, 2016; Accepted: January 27, 2016; Published: February 01, 2016|
|Citation: Patel HRH, Elbakbak W, Bouhelal A, Müller S (2016) Autophagy, Does Oral Lycopene Reduce Benign Prostate Enlargement/Hyperplasia (BPE/BPH)? Oncol Cancer Case Rep 1:108. doi:10.4172/occrs.1000108|
|Copyright: © 2016 Patel HRH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Aims: Lycopene is a potent antioxidant found in ‘Mediterranean diets’ with evidence suggesting a beneficial effect on the prostate. Our objective was to critically appraise the current literature whether Lycopene has a beneficial effect on benign prostatic enlargement.
Methods: We searched PubMed electronic databases for articles published through 2000. The following key words used: lycopene and prostate or prostrate cancer or prostatitis or BPH or BOO or LUTS or LUTD or BPE, in vitro or in vivo, animal study.
Results: The literature search identified 91 articles for analysis, 24 in vitro, 9 in vivo, 43 clinical and 15 review articles. We analyzed the papers with regards to bioavailability of lycopene, laboratory findings and clinical results of lycopene supplementation.
Conclusions: Lycopene has beneficial effects on prostate and several mechanisms of action have been identified in laboratory and clinical studies. However, the most important issue regarding future trials with lycopene is bioavailability.