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ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Research Article

Does Peripheral Neuropathy Have a Clinical Impact on the Endovascular Approach as a Primary Treatment for Limb-Threatening Ischemic Foot Wounds in Diabetic Patients?

Alexandrescu V1* and Hubermont G2

1Department of Vascular Surgery, Princess Paola Hospital, Marche-en-Famenne, Belgium

2Department of Diabetology, Princess Paola Hospital, Marche-en-Famenne, Belgium

*Corresponding Author:
Alexandrescu V
Department of Vascular Surgery
Princess Paola Hospital
Marche- en-Famenne, Belgium
E-mail: [email protected]

Received date November 01, 2011; Accepted date January 18, 2012; Published date January 24, 2012

Citation: Alexandrescu V, Hubermont G (2012) Does Peripheral Neuropathy Have a Clinical Impact on the Endovascular Approach as a Primary Treatment for Limb-Threatening Ischemic Foot Wounds in Diabetic Patients? J Diabetes Metab S5:006. doi:10.4172/2155-6156.S5-006

Copyright: © 2012 Alexandrescu V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Approximately 15% of diabetic patients will develop a foot ulcer during their lifetime and among them, 14% to 43% will require amputation [1-3]. Peripheral neuropathy, such as chronic inferior limb ischemia, is a common complication of diabetes mellitus, affecting approximately 60% of diabetic patients and up to 80% of diabetic patients with foot ulcers [1-4]. Although the neuropathic etiology is dominant in 45% of diabetic foot ulcers, both ischemic and neuropathic risk factors are found in up to 35% of cases [1-4] Current clinical management, focused on the endovascular approach as a primary treatment for critical limb ischemia (CLI), is highly feasible and shows low complication rates [5,6] and limb salvage rates comparable to surgery [5-8]. Although diabetic neuropathy has already been reported as an important risk factor for limb loss independently from limb-threatening ischemia, [1-4] there is little information on its direct effect on the outcome after surgical and endovascular reconstruction. Thus, the aim of the present study was to analyze the effect of concomitant peripheral neuropathy on critical limb ischemia in diabetic patients initially treated by endovascular methods. A retrospective design was used to assess clinical outcome in diabetic patients with ischemic foot wounds with and without concomitant peripheral neuropathy.

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