Does Pioglitazone Increase the Risk of Bladder Cancer in Japanese Diabetic Patients?Kanya Kaga, Kazuhiro Araki, Manato Kanesaka, Masahiro Sugiura, Kyokushin Ho, Hiroshi Masuda, Satoko Kojima and Yukio Naya*
Department of Urology, Teikyo Chiba Medical Center, 3426-3 Anesaki, Ichihara, Chiba 299-0111, Japan
- *Corresponding Author:
- Naya Y
Department of Urology
Teikyo Chiba Medical Center
3426-3 Anesaki, Ichihara, Chiba 299-0111, Japan
E-mail: [email protected]
Received date: March 17, 2014; Accepted date:February 10, 2015; Published date: February 14, 2015
Citation: Kaga K, Araki K, Kanesaka M, Sugiura M, Ho K, et al. (2015) Does Pioglitazone Increase the Risk of Bladder Cancer in Japanese Diabetic Patients? Med Surg Urol 4:147. doi: 10.4172/2168-9857.1000147
Copyright: © 2015 Kaga K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: To investigate the risk of bladder cancer with pioglitazone, the data of diabetic patients treated at Teikyo Chiba Medical Center were analyzed retrospectively.
Methods: From February 2009 to October 2011, 720 patients were treated with pioglitazone, and 742 patients were not treated with pioglitazone at Teikyo University Chiba Medical Center. The numbers of newly diagnosed bladder cancers from February 2009 to December 2013 in these patients and the occurrence of bladder cancer among type 2 diabetes mellitus patients were identified. The duration of diabetes, sex, age, smoking, and medication for diabetes were obtained from the medical records. The occurrence of bladder cancer was defined as incident cases after the initiation of pioglitazone. Statistical significance was analyzed by Fisher’s exact test.
Results: About 2% of diabetic patients had bladder cancer. The incidence of bladder cancer was not different between the pioglitazone group (15/720, 2.0%) and the no pioglitazone group (14/742, 1.9%). No oral diabetes medication was related to the risk of bladder cancer. However, use of insulin was significantly related to bladder cancer risk (hazard ratio [HR]: 2.83; 95% confidence interval [CI]: 1.15–6.84; p=0.0246), and sex was also significantly related to bladder cancer (HR: 6.001; 95% CI: 1.397–43.06; p=0.0137). The duration of diabetes and smoking were not associated with bladder cancer risk.
Conclusion: In this study, use of pioglitazone was not related to bladder cancer risk, while use of insulin was related to bladder cancer risk.