alexa Does Pioglitazone Increase the Risk of Bladder Cancer in Japanese Diabetic Patients? | OMICS International | Abstract
ISSN: 2168-9857

Medical & Surgical Urology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Does Pioglitazone Increase the Risk of Bladder Cancer in Japanese Diabetic Patients?

Kanya Kaga, Kazuhiro Araki, Manato Kanesaka, Masahiro Sugiura, Kyokushin Ho, Hiroshi Masuda, Satoko Kojima and Yukio Naya*

Department of Urology, Teikyo Chiba Medical Center, 3426-3 Anesaki, Ichihara, Chiba 299-0111, Japan

*Corresponding Author:
Naya Y
Department of Urology
Teikyo Chiba Medical Center
3426-3 Anesaki, Ichihara, Chiba 299-0111, Japan
Tel: +81-4-3662-1211
Fax: +81-4-3661-4773
E-mail: [email protected]

Received date: March 17, 2014; Accepted date:February 10, 2015; Published date: February 14, 2015

Citation: Kaga K, Araki K, Kanesaka M, Sugiura M, Ho K, et al. (2015) Does Pioglitazone Increase the Risk of Bladder Cancer in Japanese Diabetic Patients? Med Surg Urol 4:147. doi: 10.4172/2168-9857.1000147

Copyright: © 2015 Kaga K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Abstract

Objective: To investigate the risk of bladder cancer with pioglitazone, the data of diabetic patients treated at Teikyo Chiba Medical Center were analyzed retrospectively.

Methods: From February 2009 to October 2011, 720 patients were treated with pioglitazone, and 742 patients were not treated with pioglitazone at Teikyo University Chiba Medical Center. The numbers of newly diagnosed bladder cancers from February 2009 to December 2013 in these patients and the occurrence of bladder cancer among type 2 diabetes mellitus patients were identified. The duration of diabetes, sex, age, smoking, and medication for diabetes were obtained from the medical records. The occurrence of bladder cancer was defined as incident cases after the initiation of pioglitazone. Statistical significance was analyzed by Fisher’s exact test.

Results: About 2% of diabetic patients had bladder cancer. The incidence of bladder cancer was not different between the pioglitazone group (15/720, 2.0%) and the no pioglitazone group (14/742, 1.9%). No oral diabetes medication was related to the risk of bladder cancer. However, use of insulin was significantly related to bladder cancer risk (hazard ratio [HR]: 2.83; 95% confidence interval [CI]: 1.15–6.84; p=0.0246), and sex was also significantly related to bladder cancer (HR: 6.001; 95% CI: 1.397–43.06; p=0.0137). The duration of diabetes and smoking were not associated with bladder cancer risk.

Conclusion: In this study, use of pioglitazone was not related to bladder cancer risk, while use of insulin was related to bladder cancer risk.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version