Reach Us +1-470-347-1923
Does Spasticity Reduction by Botulinum Toxin Type A Improve Upper Limb Functionality in Adult Post-Stroke Patients? A Systematic Review of Relevant Studies | Abstract
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Does Spasticity Reduction by Botulinum Toxin Type A Improve Upper Limb Functionality in Adult Post-Stroke Patients? A Systematic Review of Relevant Studies

Domenico Intiso1*, Valentina Simone2, Filomena Di Rienzo1, Andrea Santamato3, Mario Russo1, Maurizio Tolfa1, and Mario Basciani1

1Neuro-Rehabilitation Unit, Scientific Institute, Hospital ‘Casa Sollievo della Sofferenza’, Italy

2Foundation rehabilitation “Gli Angeli di P.Pio”, San Giovanni Rotondo, Italy

3Department of Physical Medicine and Rehabilitation, “OORR Hospital”, University of Foggia, Italy

Corresponding Author:
Domenico Intiso MD
Neuro-Rehabilitation Unit
Hospital Scientific Institute “Casa Sollievo della Sofferenza”
Viale dei Cappuccini, 71013 San Giovanni Rotondo (FG), Italy
Tel: 039 882 410 942
Fax: 039 882 410 942
E-mail: [email protected], [email protected]

Received date: July 02, 2013; Accepted date: October 09, 2013; Published date: October 15, 2013

Citation: Intiso D, Simone V, Rienzo FD, Santamato A, Russo M, et al. (2013) Does Spasticity Reduction by Botulinum Toxin Type A Improve Upper Limb Functionality in Adult Post-Stroke Patients? A Systematic Review of Relevant Studies. J Neurol Neurophysiol 4:167. doi:10.4172/2155-9562.1000167

Copyright: © 2013 Intiso D. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objective: Botulinum toxin type A (BTX-A) use reduces upper limb (UL) spasticity in stroke patients, but the effects
on functional recovery remain uncertain. The aim of present review was to ascertain if the reduction of spasticity by
use of BTX-A was linked to a functional gain of UL or in activity of daily living in post-stroke patients.
Data source: Search of relevant studies was conducted on MEDLINE, the Cochrane Central Register of
Controlled Trials and EMBASE (1995 to July 2012).
Study selection: Only randomized studies (RT) treating patients with UL post-stroke spasticity by BTX-A injection
were included. Prospective open label, case series, cohort studies and case reports were excluded.
Data synthesis: Thirty-four RTs were individuated, but only 16 were considered in the analysis. Trials varied
widely in methodological design and measures used in assessing UL ability. Benefit in UL functional recovery was
reported in 13 studies, but only in six the result was significant.
Conclusion: some oriented-focused movements of UL unequivocally improve after reduced spasticity by BTX-A
treatment, but evidence that arm functionality in adult post-stroke patients significantly benefit from this intervention is
still doubt. No improvement in global functionality of activity daily living was observed.


Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri and Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry


[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version