alexa
Reach Us +44-1647-403003
Double Minute Chromosomes Associated with Philadelphia Chromosome in Myeloid Leukemia. A Case Study | OMICS International | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Double Minute Chromosomes Associated with Philadelphia Chromosome in Myeloid Leukemia. A Case Study

Abolfazl Movafagh1*, Mostafa Rezaei Tavirani2 and Mohamad Hasan Heidari3

1Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3Department of Medical Anatomy, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

*Corresponding Author:
Abolfazl Movafagh, Ph.D
Associate Professor
Department of Medical Genetics
Faculty of Medicine
Shahid Beheshti University of Medical Sciences
Tehran, Iran
Fax: +98(21) 2240067 +98-21- 23872572
E-mail: [email protected]

Received Date: March 24, 2012; Accepted Date: May 28, 2012; Published Date: May 30, 2012

Citation: Movafagh A, Tavirani MR, Heidari MH (2012) Double Minute Chromosomes Associated with Philadelphia Chromosome in Meyloid Leukemia. A Case Study. J Cancer Sci Ther 4: 144-145. doi: 10.4172/1948-5956.1000129

Copyright: © 2012 Movafagh A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The Philadelphia chromosome was the first consistent cytogenetic abnormality observed in a human cancer. Several characteristic chromosome rearrangements like double minute chromosomes are known to be associated with different subtypes of myeloid leukemia. Double Minute Chromosomes are the cytogenetic hallmarks of genomic rearrangements in cancers. Two cases, one with AML-M1 and the other with CML- blast crisis, associated with double minute chromosomes and Philadelphia chromosome is presented. The additional chromosome changes to primary chromosome abnormality may be influenced by other factor like chemotherapy. The identification of two new cases with co-expression of double minute chromosomes and Ph chromosome presented here for the first time in Iran together with large Mitelman database and other pertinent website reports is discussed.

Recommended Conferences
Share This Page
Top