Double Minute Chromosomes Associated with Philadelphia Chromosome in Myeloid Leukemia. A Case Study
- *Corresponding Author:
- Abolfazl Movafagh, Ph.D
Department of Medical Genetics
Faculty of Medicine
Shahid Beheshti University of Medical Sciences
Fax: +98(21) 2240067 +98-21- 23872572
E-mail: [email protected]
Received Date: March 24, 2012; Accepted Date: May 28, 2012; Published Date: May 30, 2012
Citation: Movafagh A, Tavirani MR, Heidari MH (2012) Double Minute Chromosomes Associated with Philadelphia Chromosome in Meyloid Leukemia. A Case Study. J Cancer Sci Ther 4: 144-145. doi: 10.4172/1948-5956.1000129
Copyright: © 2012 Movafagh A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The Philadelphia chromosome was the first consistent cytogenetic abnormality observed in a human cancer. Several characteristic chromosome rearrangements like double minute chromosomes are known to be associated with different subtypes of myeloid leukemia. Double Minute Chromosomes are the cytogenetic hallmarks of genomic rearrangements in cancers. Two cases, one with AML-M1 and the other with CML- blast crisis, associated with double minute chromosomes and Philadelphia chromosome is presented. The additional chromosome changes to primary chromosome abnormality may be influenced by other factor like chemotherapy. The identification of two new cases with co-expression of double minute chromosomes and Ph chromosome presented here for the first time in Iran together with large Mitelman database and other pertinent website reports is discussed.