alexa Double Minute Chromosomes Associated with Philadelphia Chromosome in Myeloid Leukemia. A Case Study | OMICS International | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Double Minute Chromosomes Associated with Philadelphia Chromosome in Myeloid Leukemia. A Case Study

Abolfazl Movafagh1*, Mostafa Rezaei Tavirani2 and Mohamad Hasan Heidari3

1Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3Department of Medical Anatomy, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

*Corresponding Author:
Abolfazl Movafagh, Ph.D
Associate Professor
Department of Medical Genetics
Faculty of Medicine
Shahid Beheshti University of Medical Sciences
Tehran, Iran
Fax: +98(21) 2240067 +98-21- 23872572
E-mail: [email protected]

Received Date: March 24, 2012; Accepted Date: May 28, 2012; Published Date: May 30, 2012

Citation: Movafagh A, Tavirani MR, Heidari MH (2012) Double Minute Chromosomes Associated with Philadelphia Chromosome in Meyloid Leukemia. A Case Study. J Cancer Sci Ther 4: 144-145. doi: 10.4172/1948-5956.1000129

Copyright: © 2012 Movafagh A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The Philadelphia chromosome was the first consistent cytogenetic abnormality observed in a human cancer. Several characteristic chromosome rearrangements like double minute chromosomes are known to be associated with different subtypes of myeloid leukemia. Double Minute Chromosomes are the cytogenetic hallmarks of genomic rearrangements in cancers. Two cases, one with AML-M1 and the other with CML- blast crisis, associated with double minute chromosomes and Philadelphia chromosome is presented. The additional chromosome changes to primary chromosome abnormality may be influenced by other factor like chemotherapy. The identification of two new cases with co-expression of double minute chromosomes and Ph chromosome presented here for the first time in Iran together with large Mitelman database and other pertinent website reports is discussed.

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

bornova escort

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version