Drinking Water Toxicity of Sodium Fluoride in Steroid Producing Glands and Antioxidant Ascorbate Defense System in Albino Rats (Rattus norvegicus)Priyanka Mehta1* and Kunwar Bahadur Singh2
- *Corresponding Author:
- Priyanka Mehta
Udit-36A, Mahanagar Colony
Part one, Pilibheet bye pass Road
Bareilly (U.P) 243006, India
E-mail: [email protected]
Received November 28, 2011; Accepted February 25, 2012; Published February 27, 2012
Citation: Mehta P, Singh KB (2012) Drinking Water Toxicity of Sodium Fluoride in Steroid Producing Glands and Antioxidant Ascorbate Defense System in Albino Rats (Rattus norvegicus). J Environment Analytic Toxicol 2:123. doi: 10.4172/2161-0525.1000123
Copyright: © 2012 Mehta P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This investigation examined the reproductive toxic effects and oxidative stress of sodium fluoride (NaF) in male albino rats (Rattus norvegicus). The rats received acute doses of NaF as 0.5 ppm, 200 ppm and 500 ppm through drinking water for 15 days. Additionally 10 mg ascorbate was also supplemented after NaF treatment as an antidote. The dose 0.5 ppm was ineffective and 500 ppm was fatal after 4 days onwards. A significant decrease in ascorbate content of liver and increase in cholesterol content of liver and testes after 200 ppm NaF-15 days treatment was examined but their level from adrenals did not change significantly. Histological studies of testes in these animals indicated atrophy of steroidogenic cells. Almost similar results were obtained when ascorbate was supplemented as an antidote.