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ISSN: 2157-7609

Journal of Drug Metabolism & Toxicology
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Review Article

Drug Metabolism and Pharmacokinetics of Organosulfur Compounds from Garlic

Cuicui Gao, Xiaoyan Jiang, Haina Wang, Zhongxi Zhao* and Weihong Wang*

School of Pharmaceutical Sciences and Center for Pharmaceutical Research & DDS, Shandong University, Jinan, Shandong 250012, China

*Corresponding Authors:
Zhongxi Zhao
School of Pharmaceutical Sciences
Shandong University, Jinan
Shandong 250012, China
Tel: 1-86-531-8838-2187
E-mail: [email protected]
 
Weihong Wang
School of Pharmaceutical Sciences
Shandong University, Jinan
Shandong 250012, China
Tel: 1-86-531-8838-2013
E-mail: [email protected]

Received date: September 17, 2013; Accepted date: November 05, 2013; Published date: November 07, 2013

Citation: Gao C, Jiang X, Wang H, Zhao Z, Wang W (2013) Drug Metabolism and Pharmacokinetics of Organosulfur Compounds from Garlic. J Drug Metab Toxicol 4:159. doi: 10.4172/2157-7609.1000159

Copyright: © 2013 Gao C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The medicinal activities of garlic organosulfur compounds identified include antitumor, antimicrobial, antifungal, antivirus, anti-atherosclerosis, blood lipids and sugar lowering, antithrombotic, anti-hypotension and immune modulation effects. These multi-targeted new agents may be especially promising since recently developed highly specific anti-cancer agents as well as other disease treatment drugs have failed to live up to the expectations. Despite more than one thousand articles have been published on garlic organosulfur compounds, the drug metabolism and pharmacokinetics of these compounds behind their health-promoting effects are still poorly understood. In this review, we will focus on metabolic pathways and pharmacokinetics of organosulfur compounds from garlic, which is intended to fill the void on the important aspect for further nutraceutical and pharmaceutical product development of this group of compounds. The effects of these organosulfur compounds on various cytochrome P450 enzymes as well as on P-glycoprotein (P-gp) and multidrug resistance proteins (Mrp1 and Mrp 2) will also be discussed.

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