alexa Drug Resistance and Molecular Characteristics of Escherichia coli Isolates Associated with Acute Pyelonephritis
ISSN: 2155-9597

Journal of Bacteriology & Parasitology
Open Access

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Research Article

Drug Resistance and Molecular Characteristics of Escherichia coli Isolates Associated with Acute Pyelonephritis

Xao-Li Cao#, Xue-Jing Xu#, Han Shen, Zhi-Feng Zhang, Ming-Zhe Ning, Jun-Hao Chen and Han Shen*

Department of Laboratory Medicine, The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing City, Jiangsu Province, People’s Republic of China

#Equal contributors.

*Corresponding Author:
Han Shen
Department of Laboratory Medicine
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Nanjing City, Jiangsu Province
People’s Republic of China
Tel: + 86 25 83 10 53 60
Fax: + 86 25 83 30 71 15
E-mail: [email protected]

Received date: December 11, 2015; Accepted date: February 16, 2016; Published date: February 22, 2016

Citation: Cao XL, Xu XJ, Shen H, Zhang ZF, Ning MZ, et al. (2016) Drug Resistance and Molecular Characteristics of Escherichia coli Isolates Associated with Acute Pyelonephritis. J Bacteriol Parasitol 7:260. doi: 10.4172/2155-9597.1000260

Copyright: © 2016 Cao XL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Acute pyelonephritis (APN) as one of the most severe form of UTIs may result in significant morbidity. We aim to investigate the antimicrobial susceptibilities and genetic traits of Escherichia coli isolates associated with APN.

Totally, 64 APN E. coli isolates were analyzed for the antimicrobial susceptibilities, phylogenetic groups, resistance and virulence determinants, plasmid replicons, pulsed-field gel electrophoresis (PFGE), and Multi-locus sequence types (MLST).

High percentages of resistance (>65.0%) to ampicillin/sulbactam and levofloxacin were observed, imipenem and fosfomycin displayed good in vitro sensitivity (>93.0%). Most of the strains belonged to phylogenetic group D (50.6%) and B2 (21.6%), D strains were more resistant than B2 ones towards the cephalosporins tested (p0.05). Thirty-six (56.3%) blaCTX-M, 3 (4.7%) rmtB, and 13 plasmid mediated quinolone resistance (PMQR) genes were identified. Plasmid replicon IncF (54/64, 84.4%) and virulence factors (VFs) fimH (57/64, 89.1%) was the most prevalent. PFGE and MLST displayed genetic diversity. Prevalence of ompT, fdeC, PAI, and usp were higher among B2 strains than that in D ones (P<0.05). Statistical associations between antimicrobial resistances and VFs were found.

This study provides new data on the molecular epidemiology and pathogenesis of E. coli isolates associated with APN.

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